Trial reportAmerican journal of physiology. Endocrinology and metabolism2009
Magnitude and control of mitochondrial sensitivity to ADP.
Trial report in American journal of physiology. Endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- A computational analysis of the role of integrins and Rho-GTPases in the emergence and disruption of apical-basal polarization in renal epithelial cells.PLoS computational biology · 2024Article
- Nonequilibrium thermodynamics and mitochondrial protein content predict insulin sensitivity and fuel selection during exercise in human skeletal muscle.Frontiers in physiology · 2023Article
- Evaluation of Acute Supplementation With the Ketone Ester (Frontiers in physiology · 2022Article
- Energy metabolism design of the striated muscle cell.Physiological reviews · 2021Review
- Oxidative phosphorylation KBiochimica et biophysica acta. Bioenergetics · 2021Article
- Dominant and sensitive control of oxidative flux by the ATP-ADP carrier in human skeletal muscle mitochondria: Effect of lysine acetylation.Archives of biochemistry and biophysics · 2018Article
- Neuronal control of astrocytic respiration through a variant of the Crabtree effect.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- In-vivoAnalytical biochemistry · 2017Review
- Modelling in vivo creatine/phosphocreatine in vitro reveals divergent adaptations in human muscle mitochondrial respiratory control by ADP after acute and chronic exercise.The Journal of physiology · 2016Article
- Mitochondria to motion: optimizing oxidative phosphorylation to improve exercise performance.The Journal of experimental biology · 2016Review
- Adenine nucleotide translocase is acetylated in vivo in human muscle: Modeling predicts a decreased ADP affinity and altered control of oxidative phosphorylation.Biochemistry · 2014Article
- Slowed muscle oxygen uptake kinetics with raised metabolism are not dependent on blood flow or recruitment dynamics.The Journal of physiology · 2014Article
- Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis.Acta physiologica (Oxford, England) · 2013Article
- On-off asymmetries in oxygen consumption kinetics of single Xenopus laevis skeletal muscle fibres suggest higher-order control.The Journal of physiology · 2013Article
- Parameter trajectory analysis to identify treatment effects of pharmacological interventions.PLoS computational biology · 2013Article
- A computational model of torque generation: neural, contractile, metabolic and musculoskeletal components.PloS one · 2013Article
- On the kinetics of anaerobic power.Theoretical biology & medical modelling · 2012Article
- Unchanged muscle fiber conduction velocity relates to mild acidosis during exhaustive bicycling.European journal of applied physiology · 2012Article
- Article
- Kinetic control of oxygen consumption during contractions in self-perfused skeletal muscle.The Journal of physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The transduction function for ADP stimulation of mitochondrial ATP synthesis in skeletal muscle was reconstructed in vivo and in silico to investigate the magnitude and origin of mitochondrial sensitivity to cytoplasmic ADP concentration changes. Dynamic in vivo measurements of human leg muscle phosphocreatine (PCr) content during metabolic recovery from contractions were performed by (31)P-NMR spectroscopy. The cytoplasmic ADP concentration ([ADP]) and rate of oxidative ATP synthesis (Jp) at each time point were calculated from creatine kinase equilibrium and the derivative of a monoexponential fit to the PCr recovery data, respectively. Reconstructed [ADP]-Jp relations for individual muscles containing more than 100 data points were kinetically characterized by nonlinear curve fitting yielding an apparent kinetic order and ADP affinity of 1.9 +/- 0.2 and 0.022 +/- 0.003 mM, respectively (means +/- SD; n = 6). Next, in silico [ADP]-Jp relations for skeletal muscle were generated using a computational model of muscle oxidative ATP metabolism whereby model parameters corresponding to mitochondrial enzymes were randomly changed by 50-150% to determine control of mitochondrial ADP sensitivity. The multiparametric sensitivity analysis showed that mitochondrial ADP ultrasensitivity is an emergent property of the integrated mitochondrial enzyme network controlled primarily by kinetic properties of the adenine nucleotide translocator.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.