ArticleClinical cancer research : an official journal of the American Association for Cancer Research2009
Transcriptional repression and inhibition of nuclear translocation of androgen receptor by diallyl trisulfide in human prostate cancer cells.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Dietary Plant Metabolites Induced Epigenetic Modification as a Novel Strategy for the Management of Prostate Cancer.Mini reviews in medicinal chemistry · 2024Review
- Garlic Exosomes Promote Hair Growth Through the Wnt/β-catenin Pathway and Growth Factors.Cureus · 2023Article
- Diallyl Trisulfide Induces Apoptosis in Breast Ductal Carcinoma In Situ Derived and Minimally Invasive Breast Cancer Cells.Nutrients · 2022Article
- Immunomodulatory effect of diallyl sulfide on experimentally-induced benign prostate hyperplasia via the suppression of CD4+T/IL-17 and TGF-β1/ERK pathways.Inflammopharmacology · 2020Article
- Redox Modulation at Work: Natural Phytoprotective Polysulfanes FromCurrent pharmacology reports · 2018Review
- Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment.International journal of molecular sciences · 2017Review
- Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics.Prostate cancer · 2016Review
- The inhibitory effects of AR/miR-190a/YB-1 negative feedback loop on prostate cancer and underlying mechanism.Scientific reports · 2015Article
- CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling.Oncotarget · 2014Article
- Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers.Journal of computer-aided molecular design · 2014Article
- Sodium butyrate induces DRP1-mediated mitochondrial fusion and apoptosis in human colorectal cancer cells.Mitochondrion · 2014Article
- Honokiol inhibits androgen receptor activity in prostate cancer cells.The Prostate · 2014Article
- Apoptotic pathway induced by diallyl trisulfide in pancreatic cancer cells.World journal of gastroenterology · 2014Article
- Impact of JNK1, JNK2, and ligase Itch on reactive oxygen species formation and survival of prostate cancer cells treated with diallyl trisulfide.European journal of nutrition · 2012Article
- Dietary factors and epigenetic regulation for prostate cancer prevention.Advances in nutrition (Bethesda, Md.) · 2011Review
- Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide.Indian journal of experimental biology · 2011Review
- Garlic constituent diallyl trisulfide suppresses x-linked inhibitor of apoptosis protein in prostate cancer cells in culture and in vivo.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- Role of Bim in diallyl trisulfide-induced cytotoxicity in human cancer cells.Journal of cellular biochemistry · 2011Article
- Diallyl trisulfide inhibits activation of signal transducer and activator of transcription 3 in prostate cancer cells in culture and in vivo.Cancer prevention research (Philadelphia, Pa.) · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe present study was undertaken to determine the effect of diallyl trisulfide (DATS), a promising cancer chemopreventive constituent of garlic, on androgen receptor (AR) protein expression and function using prostate cancer cells. EXPERIMENTAL
designThe protein levels of AR and prostate-specific antigen (PSA) were determined by immunoblotting. The effect of DATS treatment on AR mRNA level and AR promoter activity was determined by quantitative reverse transcription-PCR and luciferase reporter assay, respectively. Expression of AR protein in poorly differentiated carcinoma and normal prostate of transgenic adenocarcinoma of mouse prostate (TRAMP) mice was determined by immunohistochemistry. Confocal microscopy was done to determine nuclear translocation of AR. Cell viability was determined by trypan blue dye exclusion assay.
resultsExposure of prostate cancer cells (LNCaP, C4-2, and TRAMP-C1) to DATS resulted in a concentration-dependent decrease in protein level of AR, which was accompanied by suppression of intracellular and secreted levels of PSA. Structure-activity studies revealed critical roles for allyl groups and the oligosulfide chain length in DATS-mediated down-modulation of AR protein. Quantitative reverse transcription-PCR showed a dose-dependent decrease in AR mRNA level, which correlated with inhibition of AR promoter activity. DATS treatment inhibited synthetic androgen (R1881)-stimulated nuclear translocation of AR in LNCaP/C4-2 cells and proliferation of LNCaP cells. Oral gavage of 2 mg/day DATS (three times per week for 13 weeks) markedly suppressed AR protein level in poorly differentiated prostate cancer in TRAMP mice.
conclusionThe present study shows, for the first time, that DATS treatment suppresses AR function in prostate cancer cells.
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