ArticleDevelopmental and comparative immunology2009
Variations in the expressed antimicrobial peptide repertoire of northern leopard frog (Rana pipiens) populations suggest intraspecies differences in resistance to pathogens.
Article in Developmental and comparative immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- The Rana sylvatica skin-secreted antimicrobial peptide (AMP) gene repertoire highlights broader patterns in anuran AMP evolution.Scientific reports · 2026Article
- Mitigation of chytridiomycosis onMicrobiology spectrum · 2025Article
- Skin microbiomes of frogs vary among body regions, revealing differences that reflect known patterns of chytrid infection.Frontiers in microbiology · 2025Article
- The role of family and environment in determining the skin bacterial communities of captive aquatic frogs, Xenopus laevis.FEMS microbiology ecology · 2024Article
- Assessing the Efficacy of Protease Inactivation for the Preservation of Bioactive Amphibian Skin Peptides.International journal of molecular sciences · 2024Article
- Tandem Mass Spectrometry de novo Sequencing of the Skin Defense Peptides of the Central Slovenian Agile FrogMolecules (Basel, Switzerland) · 2023Article
- Disease state associated with chronic toe lesions in hellbenders may alter anti-chytrid skin defenses.Scientific reports · 2023Article
- Exposure to Batrachochytrium dendrobatidis affects chemical defences in two anuran amphibians, Rana dalmatina and Bufo bufo.BMC ecology and evolution · 2021Article
- Recovery and resiliency of skin microbial communities on the southern leopard frog (Lithobates sphenocephalus) following two biotic disturbances.Animal microbiome · 2020Article
- A New Family of Diverse Skin Peptides from the Microhylid Frog GenusMolecules (Basel, Switzerland) · 2020Article
- Balancing Selection Drives the Maintenance of Genetic Variation in Drosophila Antimicrobial Peptides.Genome biology and evolution · 2019Article
- Host age alters amphibian susceptibility to Batrachochytrium dendrobatidis, an emerging infectious fungal pathogen.PloS one · 2019Article
- Frogs adapt to physiologically costly anthropogenic noise.Proceedings. Biological sciences · 2018Article
- Environmental and Host Effects on Skin Bacterial Community Composition in Panamanian Frogs.Frontiers in microbiology · 2018Article
- Selective Landscapes in newt Immune Genes Inferred from Patterns of Nucleotide Variation.Genome biology and evolution · 2016Article
- Article
- Inhibitory bacteria reduce fungi on early life stages of endangered Colorado boreal toads (Anaxyrus boreas).The ISME journal · 2016Article
- Assessing Antibacterial Potential of Components of Phyllomedusa distincta Skin and its Associated Dermal Microbiota.Journal of chemical ecology · 2016Article
- Life history linked to immune investment in developing amphibians.Conservation physiology · 2016Article
- Using "Omics" and Integrated Multi-Omics Approaches to Guide Probiotic Selection to Mitigate Chytridiomycosis and Other Emerging Infectious Diseases.Frontiers in microbiology · 2016Review
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Authors and funding
9 authors.
Funding
Abstract
The northern leopard frog (Rana pipiens or Lithobates pipiens) is historically found in most of the provinces of Canada and the northern and southwest states of the United States. In the last 50 years, populations have suffered significant losses, especially in the western regions of the species range. Using a peptidomics approach, we show that the pattern of expressed antimicrobial skin peptides of frogs from three geographically separated populations are distinct, and we report the presence of four peptides (brevinin-1Pg, brevinin-1Pl, ranatuerin-2Pb, and ranatuerin-2Pc) that have not previously been found in skin secretions. The differences in expressed peptides reflect differences in the distribution of alleles for the newly described Brevinin1.1 locus in the three populations. When enriched peptide mixtures were tested for their ability to inhibit growth of the pathogenic amphibian chytrid (Batrachochytrium dendrobatidis), peptides from Minnesota or Vermont frogs were more effective that peptides from Michigan frogs. Four of the purified peptides were tested for their ability to inhibit growth of two bacterial pathogens (Aeromonas hydrophila and Staphylococcus epidermidis) and B. dendrobatidis. Three of the four were effective inhibitors of B. dendrobatidis and S. epidermidis, but none inhibited A. hydrophila. We interpret these differences in expression and activity of antimicrobial peptides as evidence to suggest that each population may have been selected to express a suite of peptides that reflects current and past encounters with skin microbes.
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