ArticleBMC genomics2009
Polymorphic segmental duplication in the nematode Caenorhabditis elegans.
Article in BMC genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A gap-free, telomere-to-telomere genome assembly for the Caenorhabditis briggsae reference strain AF16.G3 (Bethesda, Md.) · 2026Article
- A gap-free, telomere-to-telomere genome assembly for thebioRxiv : the preprint server for biology · 2026Article
- Genomic sequence and structural variations accumulating between laboratory lineages of wild typebioRxiv : the preprint server for biology · 2026Article
- CGC1, a new reference genome forGenome research · 2025Article
- Comprehensive detection of structural variation and transposable element differences between wild type laboratory lineages ofbioRxiv : the preprint server for biology · 2023Article
- Novel and improved Caenorhabditis briggsae gene models generated by community curation.BMC genomics · 2023Article
- Increased gene dosage and mRNA expression from chromosomal duplications in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2022Article
- A Plate Based Assay for Determination of the Median Lethal Dose of 1-Hydroxyphenazine inmicroPublication biology · 2021Article
- A spontaneous complex structural variant in rcan-1 increases exploratory behavior and laboratory fitness of Caenorhabditis elegans.PLoS genetics · 2020Article
- Recompleting theGenome research · 2019Article
- The laboratory domestication of Caenorhabditis elegans.Trends in genetics : TIG · 2015Review
- Genome-wide variations in a natural isolate of the nematode Caenorhabditis elegans.BMC genomics · 2014Article
- Segmental duplications in the silkworm genome.BMC genomics · 2013Article
- Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans.PLoS genetics · 2012Article
- Large synteny blocks revealed between Caenorhabditis elegans and Caenorhabditis briggsae genomes using OrthoCluster.BMC genomics · 2010Article
- The hidden duplication past of the plant pathogen Phytophthora and its consequences for infection.BMC genomics · 2010Article
- Article
- Genomic sequence of a mutant strain of Caenorhabditis elegans with an altered recombination pattern.BMC genomics · 2010Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe nematode Caenorhabditis elegans was the first multicellular organism to have its genome fully sequenced. Over the last 10 years since the original publication in 1998, the C. elegans genome has been scrutinized and the last gaps were filled in November 2002, which present a unique opportunity for examining genome-wide segmental duplications.
resultsHere, we performed analysis of the C. elegans genome in search for segmental duplications using a new tool -- OrthoCluster -- we have recently developed. We detected 3,484 duplicated segments -- duplicons -- ranging in size from 234 bp to 108 Kb. The largest pair of duplicons, 108 kb in length located on the left arm of Chromosome V, was further characterized. They are nearly identical at the DNA level (99.7% identity) and each duplicon contains 26 putative protein coding genes. Genotyping of 76 wild-type strains obtained from different labs in the C. elegans community revealed that not all strains contain this duplication. In fact, only 29 strains carry this large segmental duplication, suggesting a very recent duplication event in the C. elegans genome.
conclusionThis report represents the first demonstration that the C. elegans laboratory wild-type N2 strains has acquired large-scale differences.
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