ArticleCell proliferation2009
An integrative computational model for intestinal tissue renewal.
Article in Cell proliferation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Artificial Intelligence Virtual Organoids (AIVOs).Bioactive materials · 2026Review
- Emergent stable tissue shapes from the regulatory feedback between morphogens and cell growth.Journal of theoretical biology · 2026Article
- The Role of Fibroblast-Epithelial Cross-Talk on the Distribution of Distinct Fibroblast Phenotypes in the Intestinal Crypt.Bulletin of mathematical biology · 2026Article
- Emergent Stable Tissue Shapes from the Regulatory Feedback between Morphogens and Cell Growth.bioRxiv : the preprint server for biology · 2025Article
- Article
- Exploring the Role of Genetic and Environmental Features in Colorectal Cancer Development: An Agent-Based Approach.Entropy (Basel, Switzerland) · 2024Article
- Using picoliter droplet deposition to track clonal competition in adherent and organoid cancer cell cultures.Scientific reports · 2023Article
- Stochastic model for cell population dynamics quantifies homeostasis in colonic crypts and its disruption in early tumorigenesis.Proceedings. Biological sciences · 2023Article
- Free and Interfacial Boundaries in Individual-Based Models of Multicellular Biological systems.Bulletin of mathematical biology · 2023Article
- Nanoparticle-mediated cancer cell therapy: basic science to clinical applications.Cancer metastasis reviews · 2023Review
- In-silico and in-vitro morphometric analysis of intestinal organoids.PLoS computational biology · 2023Article
- Seven challenges in the multiscale modeling of multicellular tissues.WIREs mechanisms of disease · 2022Review
- Relating simulation studies by provenance-Developing a family of Wnt signaling models.PLoS computational biology · 2021Article
- Regenerative medicine meets mathematical modelling: developing symbiotic relationships.NPJ Regenerative medicine · 2021Review
- Intestinal villus structure contributes to even shedding of epithelial cells.Biophysical journal · 2021Article
- Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt.BMC bioinformatics · 2020Article
- A system-level mechanistic explanation for asymmetric stem cell fates: Arabidopsis thaliana root niche as a study system.Scientific reports · 2020Article
- Cross-talk between Hippo and Wnt signalling pathways in intestinal crypts: Insights from an agent-based model.Computational and structural biotechnology journal · 2020Article
- A multiscale mathematical model of cell dynamics during neurogenesis in the mouse cerebral cortex.BMC bioinformatics · 2019Article
- Evolution of cooperation in an epithelium.Journal of the Royal Society, Interface · 2019Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
objectivesThe luminal surface of the gut is lined with a monolayer of epithelial cells that acts as a nutrient absorptive engine and protective barrier. To maintain its integrity and functionality, the epithelium is renewed every few days. Theoretical models are powerful tools that can be used to test hypotheses concerning the regulation of this renewal process, to investigate how its dysfunction can lead to loss of homeostasis and neoplasia, and to identify potential therapeutic interventions. Here we propose a new multiscale model for crypt dynamics that links phenomena occurring at the subcellular, cellular and tissue levels of organisation.
methodsAt the subcellular level, deterministic models characterise molecular networks, such as cell-cycle control and Wnt signalling. The output of these models determines the behaviour of each epithelial cell in response to intra-, inter- and extracellular cues. The modular nature of the model enables us to easily modify individual assumptions and analyse their effects on the system as a whole.
resultsWe perform virtual microdissection and labelling-index experiments, evaluate the impact of various model extensions, obtain new insight into clonal expansion in the crypt, and compare our predictions with recent mitochondrial DNA mutation data.
conclusionsWe demonstrate that relaxing the assumption that stem-cell positions are fixed enables clonal expansion and niche succession to occur. We also predict that the presence of extracellular factors near the base of the crypt alone suffices to explain the observed spatial variation in nuclear beta-catenin levels along the crypt axis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.