ArticleLangmuir : the ACS journal of surfaces and colloids2009
Action at a distance: lengthening adhesion bonds with poly(ethylene glycol) spacers enhances mechanically stressed affinity for improved vascular targeting of microparticles.
Article in Langmuir : the ACS journal of surfaces and colloids, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- A multiscale modeling framework for transport of PEGy-lated lipid nanoparticle through the extracellular matrix.bioRxiv : the preprint server for biology · 2026Article
- Polyethylene Glycol (PEG)-Based Wet-Adhesive Absorbable Bone Wax for Osseous Hemostasis and Repair.International journal of molecular sciences · 2025Article
- Applications of Ultrasound-Mediated Drug Delivery and Gene Therapy.International journal of molecular sciences · 2021Review
- Molecular Ultrasound Imaging.Nanomaterials (Basel, Switzerland) · 2020Review
- Assessing and improving the biocompatibility of microfluidic artificial lungs.Acta biomaterialia · 2020Article
- Nonfouling NTA-PEG-Based TEM Grid Coatings for Selective Capture of Histidine-Tagged Protein Targets from Cell Lysates.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- Differential Impact of Plasma Proteins on the Adhesion Efficiency of Vascular-Targeted Carriers (VTCs) in Blood of Common Laboratory Animals.Bioconjugate chemistry · 2015Article
- Aptamer Microarrays-Current Status and Future Prospects.Microarrays (Basel, Switzerland) · 2015Review
- Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation.Biomaterials · 2014Article
- Ultrasound contrast materials in cardiovascular medicine: from perfusion assessment to molecular imaging.Journal of cardiovascular translational research · 2013Review
- Targeting of ICAM-1 on vascular endothelium under static and shear stress conditions using a liposomal Gd-based MRI contrast agent.Journal of nanobiotechnology · 2012Article
- Factors affecting the endothelial retention of targeted microbubbles: influence of microbubble shell design and cell surface projection of the endothelial target molecule.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2012Article
- Targeted binding of PEG-lipid modified polymer ultrasound contrast agents with tiered surface architecture.Biotechnology and bioengineering · 2010Article
- Nano-motion dynamics are determined by surface-tethered selectin mechanokinetics and bond formation.PLoS computational biology · 2009Article
- Targeting of microbubbles: contrast agents for ultrasound molecular imaging.Journal of drug targetingReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Poly(ethylene glycol) (PEG) chains were used to decorate microparticles with long adhesion ligands to emulate the efficacy of selectin-mediated leukocyte homing mechanisms. Ligands for P-selectin, an endothelial cell inflammatory marker, were coupled to PEG spacers of two sizes (MW 3400 and 10,000 Da) to investigate the effects on adhesion kinetics to P-selectin substrates. Under shear flow 80 nm PEG spacers improved P-selectin-antibody adhesion frequency by up to 4.5-fold and bond lifetimes by 7-fold compared to microparticles bearing chemisorbed antibody. Presentation of the glycosulfopeptide P-selectin ligands (2-GSP-6) and its nonsulfated low affinity form (2-GP-6) by long PEG spacers led to improved lifetimes of stressed bonds formed with P-selectin in shear flow and the rolling fluxes. Thus, structural features far removed from the binding pocket of a receptor that increase molecular contour length may enhance affinity in mechanically stressed environments such as those existing within the confines of the blood vessel. Such features may be useful for improving the performance of vascular-targeted micro- and nanoparticles used for drug, gene, and image contrast delivery. Ligand presentation on molecularly extended stalks may also serve to enhance any particle-surface interaction that takes place in laminar shear flow.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.