ArticleGenesis (New York, N.Y. : 2000)2009
Left-right asymmetry in the chick embryo requires core planar cell polarity protein Vangl2.
Article in Genesis (New York, N.Y. : 2000), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Breaking Left-Right Symmetry by the Interplay of Planar Cell Polarity, Calcium Signaling and Cilia.Cells · 2024Review
- Collective intelligence: A unifying concept for integrating biology across scales and substrates.Communications biology · 2024Review
- Planar cell polarity signaling in the development of left-right asymmetry.Current opinion in cell biology · 2020Review
- VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland.Scientific reports · 2019Article
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- Article
- Conserved roles for cytoskeletal components in determining laterality.Integrative biology : quantitative biosciences from nano to macro · 2016Review
- The chicken left right organizer has nonmotile cilia which are lost in a stage-dependent manner in the talpid(3) ciliopathy.Genesis (New York, N.Y. : 2000) · 2014Article
- Morpholinos: studying gene function in the chick.Methods (San Diego, Calif.) · 2014Article
- It's never too early to get it Right: A conserved role for the cytoskeleton in left-right asymmetry.Communicative & integrative biology · 2013Article
- A unified model for left-right asymmetry? Comparison and synthesis of molecular models of embryonic laterality.Developmental biology · 2013Review
- Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development.PloS one · 2013Article
- Alternative Wnt pathways and receptors.Cold Spring Harbor perspectives in biology · 2012Review
- Early, nonciliary role for microtubule proteins in left-right patterning is conserved across kingdoms.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Polarity proteins are required for left-right axis orientation and twin-twin instruction.Genesis (New York, N.Y. : 2000) · 2012Article
- The multiple roles of Notch signaling during left-right patterning.Cellular and molecular life sciences : CMLS · 2011Review
- Principles of planar polarity in animal development.Development (Cambridge, England) · 2011Review
- Non-cell-autonomous planar cell polarity propagation in the auditory sensory epithelium of vertebrates.Developmental biology · 2011Article
- Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Review
- Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning.Developmental biology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Consistent left-right patterning is a fascinating and biomedically important problem. In the chick embryo, it is not known how cells determine their position (left or right) relative to the primitive streak, which is required for subsequent asymmetric gene expression cascades. We show that the subcellular localization of Vangl2, a core planar cell polarity (PCP) protein, is consistently polarized, giving cells in the blastoderm a vector pointing toward the primitive streak. Moreover, morpholino-mediated loss-of-function of Vangl2 by electroporation into chicks at very early stages randomizes the normally left-sided expression of Sonic hedgehog. Strikingly, Vangl2 morpholinos also induce a desynchronization of asymmetric gene expression within the left and right domains of Hensen's node. These data reveal the existence of polarized planar cell polarity protein localization in gastrulating chick and demonstrate that the PCP pathway is functionally required for normal asymmetry in the chick upstream of Sonic hedgehog. These data suggest a new and widely applicable class of models for the spread and coordination of left-right patterning information in the embryonic blastoderm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.