ArticleVirchows Archiv : an international journal of pathology2009
The distribution of lesions in 1-14-mm invasive breast carcinomas and its relation to metastatic potential.
Article in Virchows Archiv : an international journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 33 citations in OpenAlex.
- Application of a novel prognostic invasive lesion index in ductal carcinoma in situ with minimal invasion of the breast.Cancer medicine · 2017Article
- The role of large-format histopathology in assessing subgross morphological prognostic parameters: a single institution report of 1000 consecutive breast cancer cases.International journal of breast cancer · 2012Article
- 3D Pathology Volumetric Technique: A Method for Calculating Breast Tumour Volume from Whole-Mount Serial Section Images.International journal of breast cancer · 2012Article
- The role of radiological-pathological correlation in diagnosing early breast cancer: the pathologist's perspective.Virchows Archiv : an international journal of pathology · 2011Review
- Redefining lumpectomy using a modification of the "sick lobe" hypothesis and ductal anatomy.International journal of breast cancer · 2011Article
- Subgross morphology, the sick lobe hypothesis, and the success of breast conservation.International journal of breast cancer · 2011Article
- Disease Extent ≥4 cm Is a Prognostic Marker of Local Recurrence in T1-2 Breast Cancer.Pathology research international · 2011Article
- Molecular phenotypes of unifocal, multifocal, and diffuse invasive breast carcinomas.Pathology research international · 2010Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyzed 301 consecutive cases of 1-14-mm invasive breast carcinomas documented in large-format histological sections to determine the distribution of invasive and in situ foci. We also aimed to determine whether this distribution was related to the frequency of demonstrable vascular invasion and lymph node metastases. One third of the carcinomas (31.9%, 96 cases) had a multifocal invasive component and a more than doubled relative risk of vascular invasion (RR = 2.3642, 95% confidence interval (CI) = 1.5077-3.7073) and lymph node metastasis (RR = 2.7760, 95% CI = 1.6337-4.7171) compared to unifocal invasive carcinomas. Invasive carcinomas with diffuse in situ component had an elevated relative risk for vascular invasion (RR = 2.2201, 95% CI = 1.4049-3.5083) and lymph node metastasis (RR = 1.9201, 95% CI = 1.1278-3.2691) compared to those with unifocal or multifocal in situ lesions. However, multifocality of the invasive component was associated with a substantially elevated risk of vascular invasion and lymph node metastasis, even in cases with diffuse in situ component. Similar observations were made in the 1-9- and 10-14-mm invasive carcinoma subgroups. These findings indicate that lesion distribution has prognostic relevance for 1-14-mm invasive breast carcinomas and underline the importance of using special techniques in breast pathology for proper assessment of this parameter.
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