ArticleExperimental brain research2010
p75 neurotrophin receptor regulates basal and fluoxetine-stimulated hippocampal neurogenesis.
Article in Experimental brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis.Frontiers in endocrinology · 2023Review
- P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke.Cell and tissue research · 2022Review
- All-trans retinoic acid induces reprogramming of canine dedifferentiated cells into neuron-like cells.PloS one · 2020Article
- Tissue-specific roles of p73 in development and homeostasis.Journal of cell science · 2019Review
- The p75Acta neuropathologica communications · 2019Article
- Reduced Anxiety-Like Behavior and Altered Hippocampal Morphology in Female p75NTR(exon IV-/-) Mice.Frontiers in behavioral neuroscience · 2016Article
- Review
- Impact of a deletion of the full-length and short isoform of p75NTR on cholinergic innervation and the population of postmitotic doublecortin positive cells in the dentate gyrus.Frontiers in neuroanatomy · 2015Article
- TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Systemic administration of low dosage of tetanus toxin decreases cell proliferation and neuroblast differentiation in the mouse hippocampal dentate gyrus.Laboratory animal research · 2013Article
- Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain.Development (Cambridge, England) · 2013Review
- The neural plasticity theory of depression: assessing the roles of adult neurogenesis and PSA-NCAM within the hippocampus.Neural plasticity · 2013Review
- Microglia modulate hippocampal neural precursor activity in response to exercise and aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is widely acknowledged that neurogenesis occurs in the adult hippocampus under normal conditions and that the rate can be regulated by environmental factors, including antidepressant drugs, with concomitant effects on behaviour. Using a quick and sensitive flow cytometry method that can assess changes in the number of bromodeoxyuridine (BrdU)-positive cells in hippocampus, in combination with traditional histological cell counts in the dentate gyrus, we report that mice lacking the p75 neurotrophin receptor gene (p75(NTR-/-)) have significantly reduced hippocampal neurogenesis. Chronic treatment with the antidepressant fluoxetine stimulated hippocampal cell proliferation in p75(NTR-/-) animals, but it did not result in an increase above basal levels of the number of newly born neurons in the dentate gyrus. These results indicate that p75(NTR) acts as a regulator of fluoxetine-stimulated as well as basal adult hippocampal neurogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.