ArticlePLoS biology2009
Emergence of a stable cortical map for neuroprosthetic control.
Article in PLoS biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 259 papers.
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Who cites it
259 citing papers in PubMed.
- Volitional control of single-electrode high gamma local field potentials by people with paralysis.Journal of neurophysiology · 2019Trial
- The Cybathlon BCI race: Successful longitudinal mutual learning with two tetraplegic users.PLoS biology · 2018Trial
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- Real-time closed-loop feedback system for mouse mesoscale cortical signal and movement control.eLife · 2026Article
- Assistive algorithms influence neural representations in motor brain-computer interfaces.Nature communications · 2026Article
- Advancing data protections for implantable brain-computer interfaces.Communications medicine · 2026Review
- The Secondary Motor Cortex-External Globus Pallidus Pathway Regulates Auditory Feedback of Volitional Control.Neuroscience bulletin · 2026Article
- Decoupling simultaneous motor imagination and execution via orthogonal ECoG neural representations.Nature communications · 2026Article
- Long-term neuron tracking reveals balance of stability and plasticity in functional properties.PloS one · 2026Article
- Brain-computer interfaces: an engineering black-box swindle or a lone advance guided by deep learning.Frontiers in neuroscience · 2026Article
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- Non-Linear Modeling and Precision Analysis Approach for Implantable Multi-Channel Neural Recording Systems.Micromachines · 2025Article
- Frontal and parietal planning signals encode adapted motor commands when learning to control a brain-computer interface.PLoS biology · 2025Article
- Effective cerebellar neuroprosthetic control after stroke.Cell reports · 2025Article
- A neural manifold view of the brain.Nature neuroscience · 2025Review
- Visual target and task-critical feedback uncertainty impair different stages of reach planning in motor cortex.Nature communications · 2025Article
- Assistive sensory-motor perturbations influence learned neural representations.bioRxiv : the preprint server for biology · 2025Article
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- Differential motor neuron activity in rats during successful and failed grasping.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- A theory of brain-computer interface learning via low-dimensional control.bioRxiv : the preprint server for biology · 2025Article
199 more citing papers are in PubMed but not listed here.
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortical control of neuroprosthetic devices is known to require neuronal adaptations. It remains unclear whether a stable cortical representation for prosthetic function can be stored and recalled in a manner that mimics our natural recall of motor skills. Especially in light of the mixed evidence for a stationary neuron-behavior relationship in cortical motor areas, understanding this relationship during long-term neuroprosthetic control can elucidate principles of neural plasticity as well as improve prosthetic function. Here, we paired stable recordings from ensembles of primary motor cortex neurons in macaque monkeys with a constant decoder that transforms neural activity to prosthetic movements. Proficient control was closely linked to the emergence of a surprisingly stable pattern of ensemble activity, indicating that the motor cortex can consolidate a neural representation for prosthetic control in the presence of a constant decoder. The importance of such a cortical map was evident in that small perturbations to either the size of the neural ensemble or to the decoder could reversibly disrupt function. Moreover, once a cortical map became consolidated, a second map could be learned and stored. Thus, long-term use of a neuroprosthetic device is associated with the formation of a cortical map for prosthetic function that is stable across time, readily recalled, resistant to interference, and resembles a putative memory engram.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.