ReviewNature immunology2009
RAG: a recombinase diversified.
Review in Nature immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre.Nucleic acids research · 2020Article
- Alterations in chromatin at antigen receptor loci define lineage progression during B lymphopoiesis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Modeling population heterogeneity from microbial communities to immune response in cells.Cellular and molecular life sciences : CMLS · 2020Review
- Intra-Vκ Cluster Recombination Shapes the Ig Kappa Locus Repertoire.Cell reports · 2019Article
- Genome organization in immune cells: unique challenges.Nature reviews. Immunology · 2019Review
- Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development.The Journal of experimental medicine · 2016Article
- Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Recombination-activating gene 1 and 2 (RAG1 and RAG2) in flounder (Paralichthys olivaceus).Journal of biosciences · 2014Article
- Role of tissue-specific AT-rich DNA sequence-binding proteins in lymphocyte differentiation.International journal of hematology · 2014Review
- Article
- Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging.Cell reports · 2013Article
- The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer.Cancer letters · 2013Review
- Review
- Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Functional characterization of an active Rag-like transposase.Nature structural & molecular biology · 2012Article
- Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination.Biochimica et biophysica acta · 2012Review
- Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.Cell reports · 2012Article
- Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination.The Journal of experimental medicine · 2011Article
- Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization.Immunologic research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During B cell and T cell development, the lymphoid-specific proteins RAG-1 and RAG-2 act together to initiate the assembly of antigen receptor genes through a series of site-specific somatic DNA rearrangements that are collectively called variable-diversity-joining (V(D)J) recombination. In the past 20 years, a great deal has been learned about the enzymatic activities of the RAG-1-RAG-2 complex. Recent studies have identified several new and exciting regulatory functions of the RAG-1-RAG-2 complex. Here we discuss some of these functions and suggest that the RAG-1-RAG-2 complex nucleates a specialized subnuclear compartment that we call the 'V(D)J recombination factory'.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.