Evidence map›Paper›PMID 19620980›Full record

ArticleNature genetics2009

Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.

Christine F Skibola, Paige M Bracci, Eran Halperin, Lucia Conde, David W Craig, Luz Agana, Kelly Iyadurai, Nikolaus Becker, Angela Brooks-Wilson, John D Curry and 7 more

Abstract read
In one paragraph

Article in Nature genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Article
  8. Article
  9. Article
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  11. Article
  12. Genetic Factors in Familial Manifestation of Primary Mediastinal Large B-Cell Lymphoma over Two Generations.Pathobiology : journal of immunopathology, molecular and cellular biology · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Follicular lymphoma: updates for pathologists.Journal of pathology and translational medicine · 2022
    Review
  17. Article
  18. Review
  19. Article
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Christine F SkibolaDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA. chrisfs@berkeley.edu
Paige M Bracci
Eran Halperin
Lucia Conde
David W Craig
Luz Agana
Kelly Iyadurai
Nikolaus Becker
Angela Brooks-Wilson
John D Curry
John J Spinelli
Elizabeth A Holly
Jacques Riby
Luoping Zhang
Alexandra Nieters
Martyn T Smith
Kevin M Brown

Funding

Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MORELLO-FROSCH, RACHEL ADELE · 1987 to 2025
$74.6M
Molecular Epidemiology of non Hodgkin's LymphomaR01CA087014 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI HOLLY, ELIZABETH A. · 2001 to 2005
$6.7M
A Genome-Wide Association Study of Non-Hodgkin LymphomaR01CA122663 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI SKIBOLA, CHRISTINE F. · 2006 to 2010
$2.7M
Genetic Susceptibility to Non-Hodgkins LymphomaR01CA104682 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI SKIBOLA, CHRISTINE F. · 2003 to 2012
$2.6M
Design and Analysis of Multi-Staged Association Studies Using Pooled Genomic DNAU01HL086528 · NHLBI · TRANSLATIONAL GENOMICS RESEARCH INST · PI CRAIG, DAVID W · 2006 to 2008
$1.1M
EPIDEMIOLOGY OF NON HODGKINS'S LYMPHOMA DATA ANALYSISR03CA089745 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI HOLLY, ELIZABETH A. · 2001 to 2002
$148k
EPIDEMIOLOGY OF NON-HODGKIN'S LYMPHOMA &RETROVIRAL TESTR01CA045614 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI HOLLY, ELIZABETH A. · 1988 to 1992
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NCI NIH HHS CA104862NCI NIH HHS CA122663NCI NIH HHS CA87014NCI NIH HHS CA89745NCI NIH HHS R01 CA045614NCI NIH HHS R01 CA087014NCI NIH HHS R01 CA104682NCI NIH HHS R01 CA122663NCI NIH HHS R03 CA089745NHLBI NIH HHS HL086528NHLBI NIH HHS U01 HL086528NIEHS NIH HHS P42 ES004705
6 · The paper itself

Abstract

We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).

Indexed as

Genetic Predisposition to DiseaseGenetic VariationChromosomes, Human, Pair 6HumansLymphoma, FollicularLymphoma, Large B-Cell, DiffusePolymorphism, Single Nucleotide

Identifiers

PMID19620980
PMCPMC2823809

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.