ArticleThe Journal of clinical investigation2009
Haptoglobin halts hemoglobin's havoc.
Article in The Journal of clinical investigation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Trial
- Acetaminophen attenuates lipid peroxidation in children undergoing cardiopulmonary bypass.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2014Trial
- Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response.Free radical biology & medicine · 2011Trial
- Hemolysis Precedes Urine Color Change in Patients Undergoing Open-Heart Surgery on Cardiopulmonary Bypass.Cureus · 2023Article
- Deferiprone-Resveratrol Hybrid, an Iron-Chelating Compound, Acts as an Antimalarial and Hepatoprotective Agent inBioinorganic chemistry and applications · 2022Article
- Heparan sulfate is a clearance receptor for aberrant extracellular proteins.The Journal of cell biology · 2020Article
- Impaired functional capacity of polarised neonatal macrophages.Scientific reports · 2020Article
- Precision Healthcare of Type 2 Diabetic Patients Through Implementation of Haptoglobin Genotyping.Frontiers in cardiovascular medicine · 2018Article
- Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate.Antioxidants & redox signaling · 2017Article
- Iron Handling in Tumor-Associated Macrophages-Is There a New Role for Lipocalin-2?Frontiers in immunology · 2017Review
- Immunological properties of oxygen-transport proteins: hemoglobin, hemocyanin and hemerythrin.Cellular and molecular life sciences : CMLS · 2017Review
- Role of Haptoglobin in Health and Disease: A Focus on Diabetes.Clinical diabetes : a publication of the American Diabetes Association · 2016Article
- Role of Exercise-Induced Oxidative Stress in Sickle Cell Trait and Disease.Sports medicine (Auckland, N.Z.) · 2016Review
- Deeper insight into chronic kidney disease-related atherosclerosis: comparative proteomic studies of blood plasma using 2DE and mass spectrometry.Journal of translational medicine · 2015Article
- Examining and mitigating acellular hemoglobin vasoactivity.Antioxidants & redox signaling · 2013Review
- α(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.The Journal of biological chemistry · 2012Article
- Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration.The Journal of biological chemistry · 2012Article
- Proximal tubule haptoglobin gene activation is an integral component of the acute kidney injury "stress response".American journal of physiology. Renal physiology · 2012Article
- Acute phase reactants as novel predictors of cardiovascular disease.ISRN inflammation · 2012Review
- Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Hemoglobin (Hb) is crucial to the function of the red blood cell. However, when it is released during intravascular hemolysis from the cell into blood plasma, it produces a state of NO depletion, oxidant stress, and vascular dysfunction, including hypertension. In their study reported in this issue of the JCI, Boretti and colleagues used canine and guinea pig models to demonstrate that pharmacological doses of glucocorticoid can increase the plasma levels of haptoglobin (Hp), the principal plasma-binding protein for free Hb (see the related article beginning on page 2271). Hp prevented Hb-induced hypertension and the generation of oxidant damage to the kidney. Neutralization of free Hb appears to be part of the downstream antiinflammatory properties of glucocorticoid.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.