ArticleProceedings of the National Academy of Sciences of the United States of America2009
Morphology and interaction between lipid domains.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Recursive feedback between Piezo1 conformation and membrane mechanics drives self-organization into finite clusters.bioRxiv : the preprint server for biology · 2026Article
- Controlled Lipid Domain Positioning and Polarization in Confined Minimal Cell Models.Angewandte Chemie (International ed. in English) · 2025Article
- Bending-driven patterning of solid inclusions in lipid membranes: Colloidal assembly and transitions in elastic 2D fluids.PNAS nexus · 2024Article
- Concealing Organic Neuromorphic Devices with Neuronal-Inspired Supported Lipid Bilayers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Kinetic control of shape deformations and membrane phase separation inside giant vesicles.Nature chemistry · 2024Article
- Bacterial lipid biophysics and membrane organization.Current opinion in microbiology · 2023Review
- DNA-Origami Line-Actants Control Domain Organization and Fission in Synthetic Membranes.Journal of the American Chemical Society · 2023Article
- Curvature-Mediated Forces on Elastic Inclusions in Fluid Interfaces.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Polymer-Lipid Hybrid Materials.Chemical reviews · 2021Review
- The Mechanics and Thermodynamics of Tubule Formation in Biological Membranes.The Journal of membrane biology · 2021Review
- Switchable positioning of plate-like inclusions in lipid membranes: Elastically mediated interactions of planar colloids in 2D fluids.Science advances · 2021Article
- Role of Lipids in Morphogenesis of T-Cell Microvilli.Frontiers in immunology · 2021Review
- Review
- All twist and no bend makes raft edges splay: Spontaneous curvature of domain edges in colloidal membranes.Science advances · 2020Article
- Observations of Membrane Domain Reorganization in Mechanically Compressed Artificial Cells.Chembiochem : a European journal of chemical biology · 2019Article
- The plasma membrane as a mechanochemical transducer.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Conformational switching of chiral colloidal rafts regulates raft-raft attractions and repulsions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Atomic force microscopy of phase separation on ruptured, giant unilamellar vesicles, and a mechanical pathway for the co-existence of lipid gel phases.Journal of biomechanical engineering · 2019Article
- Permeability and Line-Tension-Dependent Response of Polyunsaturated Membranes to Osmotic Stresses.Biophysical journal · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Cellular membranes are a heterogeneous mix of lipids, proteins and small molecules. Special groupings enriched in saturated lipids and cholesterol form liquid-ordered domains, known as "lipid rafts," thought to serve as platforms for signaling, trafficking and material transport throughout the secretory pathway. Questions remain as to how the cell maintains small fluid lipid domains, through time, on a length scale consistent with the fact that no large-scale phase separation is observed. Motivated by these examples, we have utilized a combination of mechanical modeling and in vitro experiments to show that membrane morphology plays a key role in maintaining small domain sizes and organizing domains in a model membrane. We demonstrate that lipid domains can adopt a flat or dimpled morphology, where the latter facilitates a repulsive interaction that slows coalescence and helps regulate domain size and tends to laterally organize domains in the membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.