ArticleBlood2009
The Duffy-null state is associated with a survival advantage in leukopenic HIV-infected persons of African ancestry.
Article in Blood, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
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- Notch as an Immunologic Basis of Cancer Disparities.Cancer health disparities · 2019Article
- Neutrophil Effector Functions Are Not Impaired in Duffy Antigen Receptor for Chemokines (DARC)-Null Black South Africans.Frontiers in immunology · 2019Article
- A guide to chemokines and their receptors.The FEBS journal · 2018Review
- Neutrophil, lymphocyte and platelet counts, and risk of prostate cancer outcomes in white and black men: results from the SEARCH database.Cancer causes & control : CCC · 2018Article
- Impact of genetic polymorphisms determining leukocyte/neutrophil count on chemotherapy toxicity.The pharmacogenomics journal · 2018Article
- CD235a (Glycophorin-A) Is the Most Predictive Value Among Different Circulating Cellular Microparticles in Thrombocytopenic Human Immunodeficiency Virus Type 1.Journal of clinical laboratory analysis · 2016Article
- The role of the human Duffy antigen receptor for chemokines in malaria susceptibility: current opinions and future treatment prospects.Journal of receptor, ligand and channel research · 2016Article
- Blood Groups in Infection and Host Susceptibility.Clinical microbiology reviews · 2015Review
- Studies of a murine monoclonal antibody directed against DARC: reappraisal of its specificity.PloS one · 2015Article
- Immune regulation by atypical chemokine receptors.Nature reviews. Immunology · 2013Review
- Platelets and erythrocyte-bound platelets bind infectious HIV-1 in plasma of chronically infected patients.PloS one · 2013Article
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14 authors at 7 institutions in 3 countries.
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Abstract
Persons of African ancestry, on average, have lower white blood cell (WBC) counts than those of European descent (ethnic leukopenia), but whether this impacts negatively on HIV-1 disease course remains unknown. Here, in a large natural history cohort of HIV-infected subjects, we show that, although leukopenia (< 4000 WBC/mm(3) during infection) was associated with an accelerated HIV disease course, this effect was more prominent in leukopenic subjects of European than African ancestry. The African-specific -46C/C genotype of Duffy Antigen Receptor for Chemokines (DARC) confers the malaria-resisting, Duffy-null phenotype, and we found that the recently described association of this genotype with ethnic leukopenia extends to HIV-infected African Americans (AAs). The association of Duffy-null status with HIV disease course differed according to WBC but not CD4(+) T-cell counts, such that leukopenic but not nonleukopenic HIV(+) AAs with DARC -46C/C had a survival advantage compared with all Duffy-positive subjects. This survival advantage became increasingly pronounced in those with progressively lower WBC counts. These data highlight that the interaction between DARC genotype and the cellular milieu defined by WBC counts may influence HIV disease course, and this may provide a partial explanation of why ethnic leukopenia remains benign in HIV-infected AAs, despite immunodeficiency.
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