ArticleGenetics2009
Evidence for gene length as a determinant of gene coexpression in protein complexes.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Replication-transcription collisions impose DNA strand-specific constraints on gene length in bacteria.PLoS genetics · 2026Article
- Parallel gene size and isoform expansion of ancient neuronal genes.Current biology : CB · 2024Article
- Synchronized replication of genes encoding the same protein complex in fast-proliferating cells.Genome research · 2019Article
- Intron Length Coevolution across Mammalian Genomes.Molecular biology and evolution · 2016Article
- Improving gene expression data interpretation by finding latent factors that co-regulate gene modules with clinical factors.BMC genomics · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variation of gene length imposes a challenge on genes requiring coexpression. Using a large human protein complex data set, we show that genes encoding subunits of the same protein complex tend to have similar length. The length uniformity is greater for complexes with stronger coexpression. We also show that the rate of gene length evolution is associated with gene coexpression level within a complex. These results suggest a new angle in understanding the evolution of protein complexes as well as the regulation of gene coexpression.
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Registered trials
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