ArticleAntimicrobial agents and chemotherapy2009
Novel genetic environment of the carbapenem-hydrolyzing beta-lactamase KPC-2 among Enterobacteriaceae in China.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 2 of them syntheses that pooled it.
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Who cites it
104 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk factors for carbapenem-resistantFrontiers in public health · 2026Pooled it
- Risk Factors for Carbapenem-Resistant Klebsiella pneumoniae Infection: A Meta-Analysis.Microbial drug resistance (Larchmont, N.Y.) · 2018Pooled it
- The agroenvironmental-clinical link of Proteus mirabilis: Genomic epidemiology, clonal relationships, and shared resistance and virulence profiles.Folia microbiologica · 2026Article
- Identification of IMP-8-carrying Comamonas thiooxydans strains from a diarrheal sample: genomic insights into plasmid-borne carbapenemase in an environmental bacterium.BMC genomics · 2026Article
- Emergence of hypervirulent and carbapenem-resistantFrontiers in microbiology · 2026Article
- Characterization of a conjugative IncA plasmid co-harbouringFrontiers in microbiology · 2026Article
- Review
- Genomic Characterization Reveals Infections and Silent Dissemination of Carbapenemase-Producing Klebsiella Oxytoca Complex Associated with ST2 Lineage in a Hospital Setting.Current microbiology · 2025Article
- Characterization of aMicrobiology spectrum · 2025Article
- Emergence and clonal dissemination of KPC-2- and NDM-1-coharboringMicrobiology spectrum · 2025Article
- Unraveling the genomic epidemiology and plasmid-mediated carbapenem resistance ofFrontiers in microbiology · 2025Article
- Review
- Clinical characteristics, specific resistance patterns, and molecular mechanisms of carbapenem-resistantFrontiers in cellular and infection microbiology · 2025Article
- Review
- Characterization of a Conjugative Hybrid Plasmid CoharboringMicrobiology spectrum · 2023Article
- Identification of KPC-112 from an ST15 Klebsiella pneumoniae Strain Conferring Resistance to Ceftazidime-Avibactam.mSphere · 2022Article
- Increased Expression and Amplification ofMicrobiology spectrum · 2022Article
- The Role of Plasmid and Resistance Gene Acquisition in the Emergence of ST23 Multi-Drug Resistant, Hypervirulent Klebsiella pneumoniae.Microbiology spectrum · 2022Article
- Article
- Emergence of a NDM-1-producing ST25Frontiers in microbiology · 2022Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thirty-nine bla(KPC)-producing isolates of the family Enterobacteriaceae with carbapenem resistance or reduced carbapenem susceptibility were obtained from inpatients from eight hospitals in six cities of three provinces in eastern China. The pulsed-field gel electrophoresis analysis of all 36 Klebsiella pneumoniae isolates revealed six major patterns. The resistant plasmids of most isolates were successfully transferred by conjugation and evaluated experimentally to be 40 to 180 kb in size. A 20.2-kb bla(KPC)-surrounding nucleotide sequence from plasmid pKP048 has been obtained and contains an integration structure of a Tn3-based transposon and partial Tn4401 segment, with the gene order Tn3-transposase, Tn3-resolvase, ISKpn8, the bla(KPC-2) gene, and the ISKpn6-like element. The chimera of several transposon-associated elements indicated a novel genetic environment of the K. pneumoniae carbapenemase beta-lactamase gene in isolates from China.
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