ArticleRespiratory physiology & neurobiology2009
Chronic hypoxia suppresses the CO2 response of solitary complex (SC) neurons from rats.
Article in Respiratory physiology & neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Nucleus Tractus Solitarius Neurons Activated by Hypercapnia and Hypoxia Lack Mu Opioid Receptor Expression.Frontiers in molecular neuroscience · 2022Article
- Exogenous ketone salts inhibit superoxide production in the rat caudal solitary complex during exposure to normobaric and hyperbaric hyperoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Sustained Hypoxia Alters nTS Glutamatergic Signaling and Expression and Function of Excitatory Amino Acid Transporters.Neuroscience · 2020Article
- Time Domains of the Hypoxic Ventilatory Response and Their Molecular Basis.Comprehensive Physiology · 2016Review
- Substance P differentially modulates firing rate of solitary complex (SC) neurons from control and chronic hypoxia-adapted adult rats.PloS one · 2014Article
- Ibuprofen blocks time-dependent increases in hypoxic ventilation in rats.Respiratory physiology & neurobiology · 2011Article
- Ventilatory effects of substance P-saporin lesions in the nucleus tractus solitarii of chronically hypoxic rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- CO2 chemoreception in cardiorespiratory control.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Differences between three inbred rat strains in number of K+ channel-immunoreactive neurons in the medullary raphé nucleus.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
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Authors and funding
5 authors.
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Abstract
We studied the effect of chronic hypobaric hypoxia (CHx; 10-11% O(2)) on the response to hypercapnia (15% CO(2)) of individual solitary complex (SC) neurons from adult rats. We simultaneously measured the intracellular pH and firing rate responses to hypercapnia of SC neurons in superfused medullary slices from control and CHx-adapted adult rats using the blind whole cell patch clamp technique and fluorescence imaging microscopy. We found that CHx caused the percentage of SC neurons inhibited by hypercapnia to significantly increase from about 10% up to about 30%, but did not significantly alter the percentage of SC neurons activated by hypercapnia (50% in control vs. 35% in CHx). Further, the magnitudes of the responses of SC neurons from control rats (chemosensitivity index for activated neurons of 166+/-11% and for inhibited neurons of 45+/-15%) were the same in SC neurons from CHx-adapted rats. This plasticity induced in chemosensitive SC neurons by CHx appears to involve intrinsic changes in neuronal properties since they were the same in synaptic blockade medium.
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