ArticleBiophysical journal2009
The dynamics of individual nucleosomes controls the chromatin condensation pathway: direct atomic force microscopy visualization of variant chromatin.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Direct monitoring of the stepwise condensation of kinetoplast DNA networks.Scientific reports · 2021Article
- DNA accessibility of chromatosomes quantified by automated image analysis of AFM data.Scientific reports · 2019Article
- A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A.B.PLoS genetics · 2017Article
- Assembly of nucleosomal arrays from recombinant core histones and nucleosome positioning DNA.Journal of visualized experiments : JoVE · 2013Article
- Micro- and nanofluidic technologies for epigenetic profiling.Biomicrofluidics · 2013Article
- Unwinding and rewinding the nucleosome inner turn: force dependence of the kinetic rate constants.Physical review. E, Statistical, nonlinear, and soft matter physics · 2013Article
- Kinetics and thermodynamics of phenotype: unwinding and rewinding the nucleosome.Journal of molecular biology · 2012Article
- Structure and dynamics of dinucleosomes assessed by atomic force microscopy.Journal of amino acids · 2012Article
- A unique H2A histone variant occupies the transcriptional start site of active genes.Nature structural & molecular biology · 2011Article
- The linker region of macroH2A promotes self-association of nucleosomal arrays.The Journal of biological chemistry · 2011Article
- Mechanics of the IL2RA gene activation revealed by modeling and atomic force microscopy.PloS one · 2011Article
- RSC remodeling of oligo-nucleosomes: an atomic force microscopy study.Nucleic acids research · 2011Article
- The docking domain of histone H2A is required for H1 binding and RSC-mediated nucleosome remodeling.Nucleic acids research · 2011Article
- Nucleosomes structure and dynamics: effect of CHAPS.International journal of biochemistry and molecular biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromatin organization and dynamics is studied at scales ranging from single nucleosome to nucleosomal array by using a unique combination of biochemical assays, single molecule imaging technique, and numerical modeling. We show that a subtle modification in the nucleosome structure induced by the histone variant H2A.Bbd drastically modifies the higher order organization of the nucleosomal arrays. Importantly, as directly visualized by atomic force microscopy, conventional H2A nucleosomal arrays exhibit specific local organization, in contrast to H2A.Bbd arrays, which show "beads on a string" structure. The combination of systematic image analysis and theoretical modeling allows a quantitative description relating the observed gross structural changes of the arrays to their local organization. Our results suggest strongly that higher-order organization of H1-free nucleosomal arrays is determined mainly by the fluctuation properties of individual nucleosomes. Moreover, numerical simulations suggest the existence of attractive interactions between nucleosomes to provide the degree of compaction observed for conventional chromatin fibers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.