ArticleBiophysical journal2009
A 3D hybrid model for tissue growth: the interplay between cell population and mass transport dynamics.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 41 citations in OpenAlex.
- Gelatin Methacrylate as a Mesenchymal Stem Cell Delivery Vehicle: Experimental and Semi-Quantitative Evaluation Under Metabolic Stress.Macromolecular bioscience · 2026Article
- Scalable fabrication, compartmentalization and applications of living microtissues.Bioactive materials · 2023Article
- Oxygen Consumption Characteristics in 3D Constructs Depend on Cell Density.Frontiers in bioengineering and biotechnology · 2019Article
- A poroelastic mixture model of mechanobiological processes in biomass growth: theory and application to tissue engineering.Meccanica · 2017Article
- Adult Stem Cell Therapies for Wound Healing: Biomaterials and Computational Models.Frontiers in bioengineering and biotechnology · 2015Review
- Microscale diffusion measurements and simulation of a scaffold with a permeable strut.International journal of molecular sciences · 2013Article
- Nonsteady state oxygen transport in engineered tissue: implications for design.Tissue engineering. Part A · 2013Article
- Geometry-driven cell organization determines tissue growths in scaffold pores: consequences for fibronectin organization.PloS one · 2013Article
- Article
- Rule-Based Simulation of Multi-Cellular Biological Systems-A Review of Modeling Techniques.Cellular and molecular bioengineering · 2009Article
- Mathematical and computational models for bone tissue engineering in bioreactor systems.Journal of tissue engineeringArticle
- Injectable scaffold materials differ in their cell instructive effects on primary human myoblasts.Journal of tissue engineeringArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
To provide theoretical guidance for the design and in vitro cultivation of bioartificial tissues, we have developed a multiscale computational model that can describe the complex interplay between cell population and mass transport dynamics that governs the growth of tissues in three-dimensional scaffolds. The model has three components: a transient partial differential equation for the simultaneous diffusion and consumption of a limiting nutrient; a cellular automaton describing cell migration, proliferation, and collision; and equations that quantify how the varying nutrient concentration modulates cell division and migration. The hybrid discrete-continuous model was parallelized and solved on a distributed-memory multicomputer to study how transport limitations affect tissue regeneration rates under conditions encountered in typical bioreactors. Simulation results show that the severity of transport limitations can be estimated by the magnitude of two dimensionless groups: the Thiele modulus and the Biot number. Key parameters including the initial seeding mode, cell migration speed, and the hydrodynamic conditions in the bioreactor are shown to affect not only the overall rate, but also the pattern of tissue growth. This study lays the groundwork for more comprehensive models that can handle mixed cell cultures, multiple nutrients and growth factors, and other cellular processes, such as cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.