ArticleComparative medicine2009
Left ventricular remodeling after myocardial infarction: characterization of a swine model on beta-blocker therapy.
Article in Comparative medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Human-umbilical cord matrix mesenchymal cells improved left ventricular contractility independently of infarct size in swine myocardial infarction with reperfusion.Frontiers in cardiovascular medicine · 2023Article
- Sex differences in cardiac remodeling post myocardial infarction with acute cigarette smoking.Biology of sex differences · 2022Article
- Cardioprotective effect of silicon-built restraint device (ASD), for left ventricular remodeling in rat heart failure model.Journal of materials science. Materials in medicine · 2022Article
- Application of Hybrid Matrix Metalloproteinase-Targeted and DynamicCirculation. Cardiovascular imaging · 2019Article
- In vivo magnetic resonance elastography to estimate left ventricular stiffness in a myocardial infarction induced porcine model.Journal of magnetic resonance imaging : JMRI · 2017Article
- Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes.PLoS computational biology · 2016Article
- Synergistic Effects of Combined Cell Therapy for Chronic Ischemic Cardiomyopathy.Journal of the American College of Cardiology · 2015Article
- Creation of clinically relevant model of chronic heart failure: Application of multi-modality imaging to define physiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Development of a closed chest model of chronic myocardial infarction in Swine: magnetic resonance imaging and pathological evaluation.ISRN cardiology · 2013Article
- Sulfur dioxide inhibits excessively activated endoplasmic reticulum stress in rats with myocardial injury.Heart and vessels · 2012Article
- Model-specific selection of molecular targets for heart failure gene therapy.The journal of gene medicine · 2011Review
- Gene transfer for ischemic heart failure in a preclinical model.Journal of visualized experiments : JoVE · 2011Article
- Cytokine combination therapy with erythropoietin and granulocyte colony stimulating factor in a porcine model of acute myocardial infarction.Cardiovascular drugs and therapy · 2010Article
- Cardiac regeneration using human embryonic stem cells: producing cells for future therapy.Regenerative medicine · 2010Review
- Xenon protects left ventricular diastolic function during acute ischemia, less than ischemic preconditioning.Medical gas researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current guidelines recommend beta blockers for patients after myocardial infarction (MI). Novel therapies for heart failure should be tested in combination with this medication before entering clinical trials. In this methodologic study, we sought to describe the time course of systolic and diastolic parameters of cardiac performance over a 6-wk period in closed-chest model of swine MI treated with a beta blocker. Myocardial infarction in pigs (n = 10) was induced by 90-min balloon occlusion of the left anterior descending coronary artery. Echocardiography and pressure-volume data were collected before and at 1 and 6 wk after MI; histopathology was assessed at 6 wk. Left-ventricular (LV) volume increased significantly over 6 wk, with significant decreases in ejection fraction, wall motion index, stroke work, rate of pressure development (dP/dt(max)), preload recruitable stroke work, and mechanical efficiency. Impairment of diastolic function was manifested by a significant increase in the exponential beta coefficient of the LV end-diastolic pressure-volume relation and reduction of LV pressure decay. At 6 wk, histopathologic analysis showed that the size of the infarct area was 16.3% +/- 4.4%, and the LV mass and myocyte cross-sectional area in both the infarct border and remote zones were increased compared with those of noninfarcted pigs (n = 5). These findings suggest a dynamic pattern of remodeling over time in a closed-chest ischemia-reperfusion swine model of acute MI on beta-blocker therapy and may guide future studies.
Indexed as
Identifiers
19619418PMC2733287W1563515539What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.