ArticleMuscle & nerve2009
Noninvasive model of sciatic nerve conduction in healthy and septic mice: reliability and normative data.
Article in Muscle & nerve, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
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- Histological and Functional Changes Induced by Compression and Decompression Develop Slower in Diabetic Nerves Than in Nondiabetic Nerves.BioMed research international · 2026Article
- Evolution of spinal evoked compound action potential thresholds, visual motor thresholds, and impedances in a rodent spared nerve injury model.Frontiers in neuroscience · 2025Article
- From Gut to Blood: Spatial and Temporal Pathobiome Dynamics during Acute Abdominal Murine Sepsis.Microorganisms · 2023Article
- A mouse model of peripheral nerve injury induced by Japanese encephalitis virus.PLoS neglected tropical diseases · 2022Article
- Pharmacodynamics, toxicology and toxicokinetics of ropivacaine oil delivery depot.BMC anesthesiology · 2022Article
- Glial cell line-derived neurotrophic factor (GDNF) attenuates the peripheral neuromuscular dysfunction without inhibiting the activation of spinal microglia/monocyte.BMC geriatrics · 2018Article
- NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness.Journal of immunology research · 2018Article
- Electroacupuncture alleviates neuromuscular dysfunction in an experimental rat model of immobilization.Oncotarget · 2017Article
- 4-Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury.EMBO molecular medicine · 2016Article
- In vivo electrophysiological measurements on mouse sciatic nerves.Journal of visualized experiments : JoVE · 2014Article
- Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration.Neurobiology of disease · 2013Article
- Fluorescent peptides highlight peripheral nerves during surgery in mice.Nature biotechnology · 2011Article
- The effects of anesthesia on measures of nerve conduction velocity in male C57Bl6/J mice.Neuroscience letters · 2010Article
- 4-AP-3-MeOH Promotes Structural and Functional Spontaneous Recovery in the Acute Sciatic Nerve Stretch Injury.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Neuromuscular disorders frequently complicate sepsis and other critical illnesses in patients. Mice are the major species used as a model for sepsis. Nerve conduction studies (NCS), the primary tool for noninvasive assessment of nerve and muscle function, is challenging to perform in small animals. A reliable method for noninvasive, repeated NCS testing has not been reported in mice. We developed and validated a method for the repeated measurement of mouse sciatic nerve conduction in normal and septic mice. Our sedated and awake NCS system enabled minimally invasive long-term repeated measurements. The mean compound muscle action potential (CMAP) amplitude and latency were 17.4 mV and 1.11 ms, respectively (n = 59). There was an excellent intertester reproducibility by linear regression in both normal (r = 0.95) and septic (r = 0.98) mice. We also showed significant, time-dependent isoflurane-induced CMAP suppression in all animals, which was further exacerbated in septic mice. This study provides a new tool for the assessment of peripheral nerve/muscle function in mouse neuromuscular disease models that require repeated, long-term, and minimally invasive monitoring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.