ArticlePflugers Archiv : European journal of physiology2009
Functional expression of the oligopeptide transporter PepT1 from the sea bass (Dicentrarchus labrax).
Article in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- The teleost fish PepT1-type peptide transporters and their relationships with neutral and charged substrates.Frontiers in physiology · 2023Article
- The "www" ofMembranes · 2022Review
- Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters.The Journal of physiology · 2022Article
- Absorption of protein in teleosts: a review.Fish physiology and biochemistry · 2021Review
- Effects of Short-Term Fasting on mRNA Expression of Ghrelin and the Peptide Transporters PepT1 and 2 in Atlantic Salmon (Frontiers in physiology · 2021Article
- The peptide transporter 1a of the zebrafishGenes & nutrition · 2019Article
- Dietary salt levels affect digestibility, intestinal gene expression, and the microbiome, in Nile tilapia (Oreochromis niloticus).PloS one · 2018Article
- Di- and tripeptide transport in vertebrates: the contribution of teleost fish models.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
- Salinity-Dependent Shift in the Localization of Three Peptide Transporters along the Intestine of the Mozambique Tilapia (Frontiers in physiology · 2017Article
- Amino acid transporter B(0)AT1 (slc6a19) and ancillary protein: impact on function.Pflugers Archiv : European journal of physiology · 2016Article
- Teleost fish models in membrane transport research: the PEPT1(SLC15A1) H+-oligopeptide transporter as a case study.The Journal of physiology · 2014Review
- Inhibition of myostatin gene expression in skeletal muscle of fish by in vivo electrically mediated dsRNA and shRNAi delivery.Molecular biotechnology · 2013Article
- Temperature effects on the kinetic properties of the rabbit intestinal oligopeptide cotransporter PepT1.Pflugers Archiv : European journal of physiology · 2012Article
- Functional and structural determinants of reverse operation in the pH-dependent oligopeptide transporter PepT1.Cellular and molecular life sciences : CMLS · 2011Article
- Residues R282 and D341 act as electrostatic gates in the proton-dependent oligopeptide transporter PepT1.The Journal of physiology · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complementary RNA, derived from the intestine of the sea bass Dicentrarchus labrax and putatively coding for a pH-dependent oligopeptide transporter PepT1 (SLC15 family), was injected in Xenopus oocytes that were subsequently tested with electrophysiological techniques. Transport-associated currents were observed when various di- or tripeptides were applied at concentrations ranging between 0.1 and 10 mM. No currents were generated by histidine nor by other single amino acids. Sea bass PepT1 also exhibited presteady-state currents in the absence of substrates. Acidic pH slowed down the relaxation time constant of these currents and shifted both Q/V and tau/V relationships toward more positive voltages. Michaelis-Menten analysis of the transport currents showed an increase in apparent substrate affinity at acidic pH, which was very similar to that exhibited by the related transporter from zebrafish (Danio rerio), but in contrast, did not demonstrate a significant effect of pH on the maximal transport current.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.