ArticleEuropean journal of nuclear medicine and molecular imaging2009
First experience of combined cardiac PET/64-detector CT angiography with invasive angiographic validation.
Article in European journal of nuclear medicine and molecular imaging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Diagnostic Performance of Hybrid Cardiac Imaging Methods for Assessment of Obstructive Coronary Artery Disease Compared With Stand-Alone Coronary Computed Tomography Angiography: A Meta-Analysis.JACC. Cardiovascular imaging · 2018Pooled it
- Hybrid cardiac imaging: SPECT/CT and PET/CT. A joint position statement by the European Association of Nuclear Medicine (EANM), the European Society of Cardiac Radiology (ESCR) and the European Council of Nuclear Cardiology (ECNC).European journal of nuclear medicine and molecular imaging · 2011Guideline
- EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2021Article
- Hybrid anatomo-functional imaging of coronary artery disease: Beneficial irrespective of its core components.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Review
- Myocardial perfusion imaging with PET.The international journal of cardiovascular imaging · 2017Review
- Clinical Utility and Future Applications of PET/CT and PET/CMR in Cardiology.Diagnostics (Basel, Switzerland) · 2016Review
- Noninvasive cardiac imaging in suspected acute coronary syndrome.Nature reviews. Cardiology · 2016Review
- Multi-modality imaging for the assessment of myocardial perfusion with emphasis on stress perfusion CT and MR imaging.The international journal of cardiovascular imaging · 2015Review
- Noninvasive imaging in coronary artery disease.Seminars in nuclear medicine · 2014Review
- Cardiac hybrid imaging.European journal of nuclear medicine and molecular imaging · 2014Review
- Multimodality Imaging in Ischemic Cardiomyopathy.Current cardiovascular imaging reports · 2014Review
- PET/MRI: current state of the art and future potential for cardiovascular applications.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Review
- Diagnosing coronary artery disease with hybrid PET/CT: it takes two to tango.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Review
- [Hybrid imaging in diagnostics and therapy of chronic myocardial ischemia. Clinical value].Herz · 2013Article
- Multimodality imaging in interventional cardiology.Nature reviews. Cardiology · 2012Review
- Cardiac PET, CT, and MR: what are the advantages of hybrid imaging?Current cardiology reports · 2012Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
purposeDespite modern CT systems and expert evaluators, the diagnostic performance of coronary CT angiography is limited by overestimation of vessel stenosis which reduces the positive predictive value (PPV) of the test. The aim of this study was to evaluate the performance of combined cardiac PET/64-detector CT angiography.
methodsIncluded in this retrospective study were 33 consecutive patients (5 women, 28 men; mean age 61.6 years, range 47-87 years, mean BMI 27.3+/-5.2 kg/m(2)) with clinically suspected flow-limiting coronary artery disease who underwent combined cardiac PET/64-detector CT angiography and invasive angiography. Combined PET/CT images were reported by an experienced dual-accredited radiologist/nuclear physician. An experienced cardiac CT radiologist re-read the CT images without PET. Stenotic disease was defined as >50% vessel narrowing. Invasive coronary angiography was used as a reference standard. Local ethics committee approval and patient consent were obtained.
resultsCT angiography (without PET data) was concordant with invasive angiography in 31/33 patients and at a patient level, the sensitivity in detecting significant coronary artery lesions was 100%, the specificity was 82%, the PPV was 92% and the negative predictive value (NPV) was 100%. Using combined PET/CT angiography the findings were concordant with invasive angiography in 32/33 patients and at a patient level, the sensitivity was 96%, the specificity was 100%, the PPV was 100% and the NPV was 91%.
conclusionThe use of integrated cardiac PET/64-detector CT angiography is feasible and appears to improve some aspects of the diagnostic performance of 64-detector coronary artery angiography in detecting coronary artery disease.
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