ArticleExperimental brain research2009
Age-related changes in short-latency motor cortex inhibition.
Article in Experimental brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Age-Related Differences in Corticospinal Function and Muscle Strength: A Systematic Review and Meta-Analysis.The European journal of neuroscience · 2026Pooled it
- Age-Related Changes in the Plasticity of Neural Networks Assessed by Transcranial Magnetic Stimulation With Electromyography: A Systematic Review and Meta-Analysis.Frontiers in cellular neuroscience · 2019Pooled it
- A meta-analysis of the effects of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Pooled it
- Increased motor cortex inhibition as a marker of compensation to chronic pain in knee osteoarthritis.Scientific reports · 2021Trial
- The effects of transcranial alternating current stimulation (tACS) at individual alpha peak frequency (iAPF) on motor cortex excitability in young and elderly adults.Experimental brain research · 2018Trial
- The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Enhancing human strength via neural modulation: mechanisms of maximal voluntary contraction and translational interventions.Frontiers in physiology · 2025Review
- Age and visual cortex inhibition: a TMS-MRS study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Considerable effects of lateralization and aging in intracortical excitation and inhibition.Frontiers in neuroscience · 2023Article
- Cortical excitability in human somatosensory and visual cortex: implications for plasticity and learning - a minireview.Frontiers in human neuroscience · 2023Review
- Contribution of TMS and TMS-EEG to the Understanding of Mechanisms Underlying Physiological Brain Aging.Brain sciences · 2021Review
- Alterations of hand sensorimotor function and cortical motor representations over the adult lifespan.Aging · 2020Article
- Intracortical Circuits in the Contralesional Primary Motor Cortex in Patients With Chronic Stroke After Botulinum Toxin Type A Injection: Case Studies.Frontiers in human neuroscience · 2020Article
- Differential effects of aging and physical activity on corticospinal excitability of upper and lower limb muscles.Journal of neurophysiology · 2019Article
- Reduced GABAergic cortical inhibition in aging and depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Age-related changes in late I-waves influence motor cortex plasticity induction in older adults.The Journal of physiology · 2018Article
- Physical activity modulates corticospinal excitability of the lower limb in young and old adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- GABA and primary motor cortex inhibition in young and older adults: a multimodal reliability study.Journal of neurophysiology · 2017Article
- Characterizing differential poststroke corticomotor drive to the dorsi- and plantarflexor muscles during resting and volitional muscle activation.Journal of neurophysiology · 2017Article
- Blepharospasm 40 years later.Movement disorders : official journal of the Movement Disorder Society · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined whether short-latency intracortical inhibition (SICI) and/or facilitation (ICF) changes with ageing, and if this can be attributed to age-related changes in the inhibition and/or corticospinal stimulus-response curves. SICI/ICF was studied in 17 "old" (63.1 +/- 4.2 years) and 13 "young" males (20.0 +/- 2.0 years) in both hemispheres using a paired-pulse transcranial magnetic stimulation paradigm at four interstimulus intervals (1, 3, 10 and 12 ms). Motor-evoked potentials were recorded from the first dorsal interosseous muscle at rest, with a conditioning intensity set at 5% stimulator output below the active threshold (aMT). Regardless of age, SICI was greater in the left compared with the right hemisphere. SICI was increased in old men at 3 ms in the left hemisphere and at 1 ms in the in both hemispheres, but ICF was not altered. However, aMT, and hence the conditioning stimulus intensity, was higher in old men. Comparisons of pairs of young and old men with the same aMT, and of SICI curves constructed relative to aMT, failed to show any age-related increase in SICI, although age-related changes in aMT accounted for less than 20% of the variability. Corticospinal stimulus-response characteristics did not influence SICI/ICF and appear not to be altered by ageing in men. When measured in resting muscles, SICI/ICF appears unaltered by age. But it remains unknown if, when assessed during movement preparation or movement, there are changes in SICI related to functional motor changes commonly associated with ageing, such as slowing of movement.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.