ArticleMolecular and cellular biochemistry2010
Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae.
Article in Molecular and cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Local acetyl-CoA metabolism and acetate recycling as epigenetic regulators of chromatin dynamics.FEMS yeast research · 2026Review
- Divergent roles of the acetyl-CoA synthetases RkACS1 and RkACS2 in carotenoid and lipid biosynthesis in Rhodosporidium kratochvilovae.Applied microbiology and biotechnology · 2025Article
- Article
- The SESAME complex regulates cell senescence through the generation of acetyl-CoA.Nature metabolism · 2021Article
- Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics and Oncogenesis-Part 1: Acetyl-CoA, Acetogenesis and Acyl-CoA Short-Chain Synthetases.Frontiers in physiology · 2020Review
- Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression.Molecular cell · 2019Article
- Redox control of yeast Sir2 activity is involved in acetic acid resistance and longevity.Redox biology · 2019Article
- Sirtuins as Mediator of the Anti-Ageing Effects of Calorie Restriction in Skeletal and Cardiac Muscle.International journal of molecular sciences · 2018Review
- Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells.PloS one · 2017Article
- MicroRNAs in heart failure: Non-coding regulators of metabolic function.Biochimica et biophysica acta · 2016Review
- Compartmentation of metabolites in regulating epigenome of cancer.Molecular medicine (Cambridge, Mass.) · 2016Article
- Calorie restriction as an intervention in ageing.The Journal of physiology · 2016Review
- Gis1 and Rph1 regulate glycerol and acetate metabolism in glucose depleted yeast cells.PloS one · 2012Article
- Functional analyses of two acetyl coenzyme A synthetases in the ascomycete Gibberella zeae.Eukaryotic cell · 2011Article
- Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain.The Journal of comparative neurology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Acs2p is one of two acetyl-coenzyme A synthetases in Saccharomyces cerevisiae. We have prepared and characterized a monoclonal antibody specific for Acs2p and find that Acs2p is localized primarily to the nucleus, including the nucleolus, with a minor amount in the cytosol. We find that Acs2p is required for replicative longevity: an acs2 Delta strain has a reduced replicative life span compared to wild-type and acs1 Delta strains. Furthermore, replicatively aged acs2 Delta cells contain elevated levels of extrachromosomal rDNA circles, and silencing at the rDNA locus is impaired in an acs2 Delta strain. These findings indicate that Acs2p-mediated synthesis of acetyl-CoA in the nucleus functions to promote rDNA silencing and replicative longevity in yeast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.