ArticleJournal of neuro-oncology2010
Cellularity and apparent diffusion coefficient in oligodendroglial tumours characterized by genotype.
Article in Journal of neuro-oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The correlation between apparent diffusion coefficient and tumor cellularity in patients: a meta-analysis.PloS one · 2013Pooled it
- Non-invasive identification of KRAS mutation in rectal cancer using hybrid intravoxel incoherent motion and diffusion kurtosis model.World journal of surgical oncology · 2025Article
- Independent histological validation of MR-derived radio-pathomic maps of tumor cell density using image-guided biopsies in human brain tumors.Journal of neuro-oncology · 2025Article
- Structural- and DTI- MRI enable automated prediction of IDH Mutation Status in CNS WHO Grade 2-4 glioma patients: a deep Radiomics Approach.BMC medical imaging · 2024Article
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- Multi-parameter diffusion and perfusion magnetic resonance imaging and radiomics nomogram for preoperative evaluation of aquaporin-1 expression in rectal cancer.Abdominal radiology (New York) · 2022Article
- Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach.Neuroradiology · 2019Article
- Could IVIM and ADC help in predicting the KRAS status in patients with rectal cancer?European radiology · 2018Article
- Prediction ofAJNR. American journal of neuroradiology · 2018Article
- Characterization of brain tumours with spin-spin relaxation: pilot case study reveals unique TJournal of neurology · 2017Article
- Intravoxel incoherent motion diffusion-weighted imaging for discriminating the pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer.Scientific reports · 2017Article
- Cancer Metabolism and Tumor Heterogeneity: Imaging Perspectives Using MR Imaging and Spectroscopy.Contrast media & molecular imaging · 2017Review
- Molecular imaging of 1p/19q deletion in oligodendroglial tumours with 11C-methionine positron emission tomography.Journal of neurology, neurosurgery, and psychiatry · 2016Article
- Diffusion tensor imaging of breast lesions: evaluation of apparent diffusion coefficient and fractional anisotropy and tissue cellularity.The British journal of radiology · 2016Article
- Automatic Analysis of Cellularity in Glioblastoma and Correlation with ADC Using Trajectory Analysis and Automatic Nuclei Counting.PloS one · 2016Article
- High-definition fiber tractography for the evaluation of perilesional white matter tracts in high-grade glioma surgery.Neuro-oncology · 2015Review
- Genetics and imaging of oligodendroglial tumors.CNS oncology · 2015Review
- Diffusion imaging for tumor grading of supratentorial brain tumors in the first year of life.AJNR. American journal of neuroradiology · 2014Article
- Imaging in sepsis-associated encephalopathy--insights and opportunities.Nature reviews. Neurology · 2013Review
- Discrimination of paediatric brain tumours using apparent diffusion coefficient histograms.European radiology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeApparent diffusion coefficient (ADC) describes water diffusion within tissues. Previous studies report a negative linear correlation between minimum ADC and tumour cellularity in different types of gliomas, but there are no studies in oligodendroglial tumours. This study evaluated the relationship between ADC and tumour cellularity in oligodendroglial tumours characterized by genotype.
methodsADC was assessed in 17 patients with known 1p/19q status: 3 grade II oligodendrogliomas (OII), 9 grade II oligoastrocytomas (OAII), 5 grade III oligoastrocytomas (OAIII). Regions of interest were placed on ADC maps around tumour margins to generate mean tumour ADC, and over minimum and maximum tumour ADC. Histopathology assessment of tumour cellularity determined minimum, maximum and mean cell density in serial stereotactic biopsies.
results1p/19q loss was present in 2/3 OII, 5/9 OAII, 2/5 OAIII. Grade III tumours had higher maximum cell density than grade II tumours (17.2 vs. 10.57%: Mann Whitney U; P = 0.20). Oligoastrocytoma were more likely to have a lower minimum cell density than oligodendrogliomas (Mann Whitney U; P = 0.032). There was no relationship between cell density and genotype. There was no linear correlation between mean ADC and mean cell density (Spearman's rho; r = 0.486: P = 0.438), minimum ADC and maximum cell density (Spearman's rho; r = 0.158: P = 0.660), and maximum ADC and minimum cell density (Spearman's rho; r = 0.039: P = 0.985).
conclusionsIn oligodendroglial tumours there is no relationship between quantitative assessment of cellularity and ADC. This may reflect differences in oligodendroglial tumour biology compared to other gliomas, although the composition of the extracellular matrix may influence ADC more than cellularity.
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