ArticleActa pharmacologica Sinica2009
Beta-receptor activation increases sodium current in guinea pig heart.
Article in Acta pharmacologica Sinica, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Do Stimulants Promote Arrhythmic Risk: Insights From a Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Model.Journal of arrhythmia · 2026Article
- Antiarrhythmic effects of mirabegron on ventricular fibrillation in Langendorff-perfused rabbit ventricles.The Journal of physiology · 2025Article
- Bacterial toxins and heart function: heat-labileBiophysical reviews · 2023Article
- Late sodium current in synergism with CaPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Action potential responses to changes in stimulation frequency and isoproterenol in rat ventricular myocytes.Physiological reports · 2022Article
- Conduction in the right and left ventricle is differentially regulated by protein kinases and phosphatases: implications for arrhythmogenesis.American journal of physiology. Heart and circulatory physiology · 2019Article
- Concomitant SK current activation and sodium current inhibition cause J wave syndrome.JCI insight · 2018Article
- β1-Adrenergic blocker bisoprolol reverses down-regulated ion channels in sinoatrial node of heart failure rats.Journal of physiology and biochemistry · 2016Article
- Epinephrine reversed high-concentration bupivacaine-induced inhibition of calcium channels and transient outward potassium current channels, but not on sodium channel in ventricular myocytes of rats.BMC anesthesiology · 2015Article
- Signs of cardiac autonomic imbalance and proarrhythmic remodeling in FTO deficient mice.PloS one · 2014Article
- Tetrodotoxin attenuates isoproterenol-induced hypertrophy in H9c2 rat cardiac myocytes.Molecular and cellular biochemistry · 2012Article
- Electrophysiological mechanisms of sophocarpine as a potential antiarrhythmic agent.Acta pharmacologica Sinica · 2011Article
- Anger, emotion, and arrhythmias: from brain to heart.Frontiers in physiology · 2011Article
- Polymorphism of the Beta-1 Gly389Arg receptor in patients with dual atrioventricular nodal physiology.Indian pacing and electrophysiology journalArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the influence of beta-receptor activation on sodium channel current and the physiological significance of increased sodium current with regard to the increased cardiac output caused by sympathetic excitation.
methodsMultiple experimental approaches, including ECG, action potential recording with conventional microelectrodes, whole-cell current measurements, single-channel recordings, and pumping-force measurements, were applied to guinea pig hearts and isolated ventricular myocytes.
resultsIsoprenaline was found to dose-dependently shorten QRS waves, increase the amplitude and the V(max) of action potentials, augment the fast sodium current, and increase the occurrence frequencies and open time constants of the long-open and burst modes of the sodium channel. Increased levels of membrane-permeable cAMP have similar effects. In the presence of a calcium channel blocker, TTX reversed the increased pumping force produced by isoprenaline.
conclusionBeta-adrenergic modulation increases the inward sodium current and accelerates the conduction velocity within the ventricles by changing the sodium channel modes, which might both be conducive to the synchronous contraction of the heart and enhance its pumping function.
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