ReviewNature reviews. Neuroscience2009
The genetic and molecular regulation of sleep: from fruit flies to humans.
Review in Nature reviews. Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
164 citing papers in PubMed, 386 citations in OpenAlex.
- Patterns of depressive symptom remission during the treatment of seasonal affective disorder with cognitive-behavioral therapy or light therapy.Depression and anxiety · 2018Trial
- Widespread changes in white matter microstructure after a day of waking and sleep deprivation.PloS one · 2015Trial
- Article
- Trex1 overexpression leads to longer lifespans and fragmented sleep inApplied biological chemistry · 2026Article
- Biological Mechanisms of Sleep/Wake-Related Function.Biological psychiatry · 2025Review
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- Article
- The Glutamate-gated Chloride Channel Facilitates Sleep by Enhancing the Excitability of Two Pairs of Neurons in the Ventral Nerve Cord of Drosophila.Neuroscience bulletin · 2025Article
- Genome-wide identification and functional validation of the WW domain containing oxidoreductase gene associated with sleep duration.Scientific reports · 2025Article
- Activity Monitoring for Analysis of Sleep inCold Spring Harbor protocols · 2024Article
- Sleep and diurnal alternative polyadenylation sites associated with human APA-linked brain disorders.Research square · 2024Article
- Waking Up the Sleep Field: An Overview on the Implications of Genetics and Bioinformatics of Sleep.Molecular biotechnology · 2024Review
- CorticalProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sleep and diurnal alternative polyadenylation sites associated with human APA-linked brain disorders.Npj biological timing and sleep · 2024Article
- The Effects of poly-GA and poly-PRmicroPublication biology · 2024Article
- Combined Effects ofFoods (Basel, Switzerland) · 2023Article
- Oral nano-antioxidants improve sleep by restoring intestinal barrier integrity and preventing systemic inflammation.National science review · 2023Article
- In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men.Scientific reports · 2023Article
- Sleep: An Essential and Understudied Process in the Biology of Blood-Feeding Arthropods.Integrative and comparative biology · 2023Review
- The zebrafish mutanteLife · 2023Article
104 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
It has been known for a long time that genetic factors affect sleep quantity and quality. Genetic screens have identified several mutations that affect sleep across species, pointing to an evolutionary conserved regulation of sleep. Moreover, it has also been recognized that sleep affects gene expression. These findings have given valuable insights into the molecular underpinnings of sleep regulation and function that might lead the way to more efficient treatments for sleep disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.