Evidence map›Paper›PMID 19617816›Full record

ArticleAIDS (London, England)2009

HIV patients with psychiatric disorders are less likely to discontinue HAART.

Seth Himelhoch, Clayton H Brown, James Walkup, Geetanjali Chander, P Todd Korthius, Joseph Afful, Kelly A Gebo

Abstract readMulticenter Study
In one paragraph

Article in AIDS (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Mental health and retention in HIV care: A systematic review and meta-analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Seth HimelhochDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21212, USA. shimelho@psych.umaryland.edu
Clayton H Brown
James Walkup
Geetanjali Chander
P Todd Korthius
Joseph Afful
Kelly A Gebo

Funding

Center for Education and Research on Mental Health Ther*U18HS016097 · AHRQ · RUTGERS, THE STATE UNIV OF N.J. · PI CRYSTAL, STEPHEN · 2006 to 2010
$3.7M
GERIATRIC DEPRESSION AND ANTIDEPRESSANT USER01MH060831 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI CRYSTAL, STEPHEN · 2000 to 2008
$2.2M
Quality Outcomes for Patients with Drug Abuse and HIVK23DA019809 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KORTHUIS, PHILIP TODD · 2007 to 2011
$892k
HIV Care for Substance Users with Psychiatric DisordersK23DA019820 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI HIMELHOCH, SETH S · 2005 to 2009
$883k
Developing Telephone CBT for HIV Related DepressionR34MH080630 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HIMELHOCH, SETH S · 2008 to 2010
$650k
CLINICAL OUTCOMES IN ELDERLY HIV PATIENTSR01AG026250 · NIA · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2006 to 2007
$197k
AHRQ HHS HS016097AHRQ HHS U18 HS016097NIA NIH HHS R01 AG026250NIDA NIH HHS K23 DA019809NIDA NIH HHS K23-DA019809NIDA NIH HHS K23 DA019820NIDA NIH HHS K23-DA019820NIMH NIH HHS R01 MH060831NIMH NIH HHS R01-MH60831NIMH NIH HHS R34 MH080630NIMH NIH HHS R34-MH080630-02PHS HHS 290-01-012
6 · The paper itself

Abstract

objectiveWe examined whether having a psychiatric disorder among HIV-infected individuals is associated with differential rates of discontinuation of HAART and whether the number of mental health visits impact these rates.

designThis longitudinal study (fiscal year: 2000-2005) used discrete time survival analysis to evaluate time to discontinuation of HAART. The predictor variable was presence of a psychiatric diagnosis (serious mental illness versus depressive disorders versus none).

settingFive United States outpatient HIV sites affiliated with the HIV Research Network. PATIENTS: The sample consisted of 4989 patients. The majority was nonwhite (74.0%) and men (71.3%); 24.8% were diagnosed with a depressive disorder, and 9% were diagnosed with serious mental illness.

main outcome measuresTime to discontinuation of HAART adjusting for demographic factors, injection drug use history, and nadir CD4 cell count.

resultsRelative to those with no psychiatric disorders, the hazard probability for discontinuation of HAART was significantly lower in the first and second years among those with SMI [adjusted odds ratio: first year, 0.57 (0.47-0.69); second year, 0.68 (0.52-0.89)] and in the first year among those with depressive disorders [adjusted odds ratio: first year, 0.61 (0.54-0.69)]. The hazard probabilities did not significantly differ among diagnostic groups in subsequent years. Among those with psychiatric diagnoses, those with six or more mental health visits in a year were significantly less likely to discontinue HAART compared with patients with no mental health visits.

conclusionIndividuals with psychiatric disorders were significantly less likely to discontinue HAART in the first and second years of treatment. Mental health visits are associated with decreased risk of discontinuing HAART.

Indexed as

AdultAntiretroviral Therapy, Highly ActiveDepressive DisorderFemaleHIV InfectionsHumansMaleMental DisordersMental Health ServicesMiddle AgedPatient Acceptance of Health CarePatient CompliancePatient DropoutsRetrospective Studies

Identifiers

PMID19617816
PMCPMC3214621

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.