ArticleProceedings of the National Academy of Sciences of the United States of America1991
Both activation and repression of a-mating-type-specific genes in yeast require transcription factor Mcm1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 69 citations in OpenAlex.
- Article
- Homeodomain protein Sxi1α independently controls cell-cell fusion and gene expression during sexual reproduction in Cryptococcus deneoformans.PLoS genetics · 2026Article
- Homeodomain protein Sxi1α independently controls cell-cell fusion and gene expression during sexual reproduction inbioRxiv : the preprint server for biology · 2025Article
- Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III.PLoS genetics · 2023Article
- Genetic analysis argues for a coactivator function for the Saccharomyces cerevisiae Tup1 corepressor.Genetics · 2021Article
- Design of orthogonal regulatory systems for modulating gene expression in plants.Nature chemical biology · 2020Article
- Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Signature gene expression reveals novel clues to the molecular mechanisms of dimorphic transition in Penicillium marneffei.PLoS genetics · 2014Article
- RNA preparation of Saccharomyces cerevisiae using the digestion method may give misleading results.Applied biochemistry and biotechnology · 2013Article
- Review
- Review
- Integrating multiple types of data to predict novel cell cycle-related genes.BMC systems biology · 2011Article
- Coupling phosphate homeostasis to cell cycle-specific transcription: mitotic activation of Saccharomyces cerevisiae PHO5 by Mcm1 and Forkhead proteins.Molecular and cellular biology · 2009Article
- Role of Plc1p in regulation of Mcm1p-dependent genes.FEMS microbiology letters · 2009Article
- Interspecies variation reveals a conserved repressor of alpha-specific genes in Saccharomyces yeasts.Genes & development · 2008Article
- GibbsST: a Gibbs sampling method for motif discovery with enhanced resistance to local optima.BMC bioinformatics · 2006Article
- Dynamic changes in subgraph preference profiles of crucial transcription factors.PLoS computational biology · 2006Article
- Defining the mammalian CArGome.Genome research · 2006Article
- Tup1p represses Mcm1p transcriptional activation and chromatin remodeling of an a-cell-specific gene.The EMBO journal · 2000Article
- Article
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2 authors at 1 institution in 1 country.
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Abstract
Mcm1 is a yeast transcription factor with homologs throughout the metazoa. MCM1 was first identified as a gene involved in maintenance of artificial minichromosomes in yeast. More recently Mcm1 has been shown to serve as a transcriptional regulator of mating-type-specific genes. Biochemical data suggest that Mcm1 coactivates alpha-specific genes and corepresses a-specific genes by binding to a 10-base-pair dyad symmetry element in their upstream regions. We reported previously that an mcm1 point mutation reduced activation of alpha-specific genes but had little effect on the expression of a-specific genes. We now show that another mcm1 allele, which depletes the Mcm1 protein, affects both activation and repression of a-specific genes. The mutant strain remains capable of high levels of pheromone induction of a-specific genes, although with retarded kinetics. Mcm1 joins an increasing number of transcription factors involved in both positive and negative regulation of gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.