ArticleMolecular & cellular proteomics : MCP2009
Global survey of protein expression during gonadal sex determination in mice.
Article in Molecular & cellular proteomics : MCP, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Epigenetic transgenerational inheritance, gametogenesis and germline development†.Biology of reproduction · 2021Review
- The Latest Research Progress of mFrontiers in cell and developmental biology · 2021Review
- Transcriptomic and proteomic analyses of ovarian follicles reveal the role of VLDLR in chicken follicle selection.BMC genomics · 2020Article
- Gametogenesis: A journey from inception to conception.Current topics in developmental biology · 2019Review
- Quantitative Proteomics Reveals the Essential Roles of Stromal Interaction Molecule 1 (STIM1) in the Testicular Cord Formation in Mouse Testis.Molecular & cellular proteomics : MCP · 2015Article
- The sex-specific transcriptome of the hermaphrodite sparid sharpsnout seabream (Diplodus puntazzo).BMC genomics · 2014Article
- Proteome differences between male and female fetal cells in amniotic fluid.Omics : a journal of integrative biology · 2013Article
- The protein expression landscape of the Arabidopsis root.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Expression of 3β-HSD1 and P450 Aromatase enzymes during mouse gonad differentiation.Journal of molecular histology · 2011Article
- Building pathways for ovary organogenesis in the mouse embryo.Current topics in developmental biology · 2010Review
- Sex and the circuitry: progress toward a systems-level understanding of vertebrate sex determination.Wiley interdisciplinary reviews. Systems biology and medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of an embryo as male or female depends on differentiation of the gonads as either testes or ovaries. A number of genes are known to be important for gonadal differentiation, but our understanding of the regulatory networks underpinning sex determination remains fragmentary. To advance our understanding of sexual development beyond the transcriptome level, we performed the first global survey of the mouse gonad proteome at the time of sex determination by using two-dimensional nanoflow LC-MS/MS. The resulting data set contains a total of 1037 gene products (154 non-redundant and 883 redundant proteins) identified from 620 peptides. Functional classification and biological network construction suggested that the identified proteins primarily serve in RNA post-transcriptional modification and trafficking, protein synthesis and folding, and post-translational modification. The data set contains potential novel regulators of gonad development and sex determination not revealed previously by transcriptomics and proteomics studies and more than 60 proteins with potential links to human disorders of sexual development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.