ArticleProceedings of the National Academy of Sciences of the United States of America2009
Transcriptome of embryonic and neonatal mouse cortex by high-throughput RNA sequencing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 80 citations in OpenAlex.
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- Inapparent maternal ZIKV infection impacts fetal brain development and postnatal behavior.PLoS pathogens · 2026Article
- Nutrient sensitive proteinLife science alliance · 2022Article
- The Toggle Switch Model for Gene Expression Change during the Prenatal-to-Postnatal Transition in Mammals.Molecular biology and evolution · 2022Article
- Pathogenic Infections during Pregnancy and the Consequences for Fetal Brain Development.Pathogens (Basel, Switzerland) · 2022Review
- A Cellular Resolution Spatial Transcriptomic Landscape of the Medial Structures in Postnatal Mouse Brain.Frontiers in cell and developmental biology · 2022Article
- Maternal nematode infection upregulates expression of Th2/Treg and diapedesis related genes in the neonatal brain.Scientific reports · 2021Article
- RNA-Seq Transcriptome Analysis of the Liver and Brain of the Black Carp (Mylopharyngodon piceus) During Fasting.Marine biotechnology (New York, N.Y.) · 2021Article
- Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle.BMC genomics · 2021Article
- Comprehensive transcriptional changes in the liver of Kanglang white minnow (Animals : an open access journal from MDPI · 2020Article
- Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex.Neurobiology of disease · 2019Article
- Article
- Maternal Gastrointestinal Nematode Infection Up-regulates Expression of Genes Associated with Long-Term Potentiation in Perinatal Brains of Uninfected Developing Pups.Scientific reports · 2019Article
- Article
- Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury.Cell reports · 2017Article
- RNA sequencing analysis to capture the transcriptome landscape during skin ulceration syndrome progression in sea cucumber Apostichopus japonicus.BMC genomics · 2016Article
- Expression and localization of Inter-alpha Inhibitors in rodent brain.Neuroscience · 2016Article
- Liver Transcriptome Analysis of the Large Yellow Croaker (Larimichthys crocea) during Fasting by Using RNA-Seq.PloS one · 2016Article
- Suspension arrays based on nanoparticle-encoded microspheres for high-throughput multiplexed detection.Chemical Society reviews · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
Abstract
Brain structure and function experience dramatic changes from embryonic to postnatal development. Microarray analyses have detected differential gene expression at different stages and in disease models, but gene expression information during early brain development is limited. We have generated >27 million reads to identify mRNAs from the mouse cortex for >16,000 genes at either embryonic day 18 (E18) or postnatal day 7 (P7), a period of significant synaptogenesis for neural circuit formation. In addition, we devised strategies to detect alternative splice forms and uncovered more splice variants. We observed differential expression of 3,758 genes between the 2 stages, many with known functions or predicted to be important for neural development. Neurogenesis-related genes, such as those encoding Sox4, Sox11, and zinc-finger proteins, were more highly expressed at E18 than at P7. In contrast, the genes encoding synaptic proteins such as synaptotagmin, complexin 2, and syntaxin were up-regulated from E18 to P7. We also found that several neurological disorder-related genes were highly expressed at E18. Our transcriptome analysis may serve as a blueprint for gene expression pattern and provide functional clues of previously unknown genes and disease-related genes during early brain development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.