ArticleProceedings of the National Academy of Sciences of the United States of America1991
Structure of the human villin gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- Development and characterization of 2-dimensional culture for buffalo intestinal cells.Cytotechnology · 2018Article
- The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury.PloS one · 2013Article
- Villin-like actin-binding proteins are expressed ubiquitously in Arabidopsis.Plant physiology · 2000Article
- Assignment of the locus for a new lethal neonatal metabolic syndrome to 2q33-37.American journal of human genetics · 1998Article
- Human fetal enterocytes in vitro: modulation of the phenotype by extracellular matrix.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Molecular and mutational analysis of a gelsolin-family member encoded by the flightless I gene of Drosophila melanogaster.Genetics · 1995Article
- Suppression of villin expression by antisense RNA impairs brush border assembly in polarized epithelial intestinal cells.The EMBO journal · 1995Article
- In vivo analysis of functional domains from villin and gelsolin.The Journal of cell biology · 1992Article
- Transcriptional activation of the human villin gene during enterocyte differentiation.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated and characterized the complete human villin gene. The villin gene is located on chromosome 2q35-36 in humans and on chromosome 1 in mice. Villin belongs to a family of calcium-regulated actin-binding proteins that share structural and functional homologies. The villin gene is expressed mainly in cells that develop a brush border, such as mucosal cells of the small and large intestine and epithelial cells of the kidney proximal tubules. Villin gene expression is strictly regulated during adult life and embryonic development in the digestive and urogenital tracts and, thus, may be used as a marker of the digestive and renal cell lineages. The human villin gene has one copy per haploid genome, encompasses about 25 kilobases, and contains 19 exons. Analysis of the structural organization of this gene shows that the two mRNAs that encode villin in humans arise by alternative choice of one of the two polyadenylylation signals located within the last exon. The overall organization of the exons reflects the gene duplication event from which this family of actin-binding proteins originated.
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