ArticleJournal of the American Society for Mass Spectrometry2009
Improving FAIMS sensitivity using a planar geometry with slit interfaces.
Article in Journal of the American Society for Mass Spectrometry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Performance Enhancements in Differential Ion Mobility Spectrometry-Mass Spectrometry (DMS-MS) by Using a Modified CaptiveSpray Source.Journal of the American Society for Mass Spectrometry · 2018Article
- Article
- Review on ion mobility spectrometry. Part 1: current instrumentation.The Analyst · 2015Review
- On an aerodynamic mechanism to enhance ion transmission and sensitivity of FAIMS for nano-electrospray ionization-mass spectrometry.Journal of the American Society for Mass Spectrometry · 2014Article
- Size, weight and position: ion mobility spectrometry and imaging MS combined.Analytical and bioanalytical chemistry · 2011Review
- Ultrahigh-resolution differential ion mobility spectrometry using extended separation times.Analytical chemistry · 2011Article
- Separation of peptide isomers with variant modified sites by high-resolution differential ion mobility spectrometry.Analytical chemistry · 2010Article
- High-resolution differential ion mobility separations using helium-rich gases.Analytical chemistry · 2010Article
- Chemical effects in the separation process of a differential mobility/mass spectrometer system.Analytical chemistry · 2010Article
- Differential ion mobility separations of peptides with resolving power exceeding 50.Analytical chemistry · 2010Article
- Ultrafast differential ion mobility spectrometry at extreme electric fields coupled to mass spectrometry.Analytical chemistry · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Differential mobility spectrometry or field asymmetric waveform ion mobility spectrometry (FAIMS) is gaining broad acceptance for analyses of gas-phase ions, especially in conjunction with largely orthogonal separation methods such as mass spectrometry (MS) and/or conventional (drift tube) ion mobility spectrometry. In FAIMS, ions are filtered while passing through a gap between two electrodes that may have planar or curved (in particular, cylindrical) geometry. Despite substantial inherent advantages of the planar configuration and its near-universal adoption in current stand-alone FAIMS devices, commercial FAIMS/MS systems have employed curved FAIMS geometries that can be more effectively interfaced to MS. Here we report a new planar (p-) FAIMS design with slit-shaped entrance and exit apertures that substantially increase ion transmission in and out of the analyzer. The entrance slit interface effectively couples p-FAIMS to multi-emitter electrospray ionization (ESI) sources, improving greatly the ion current introduced to the device and allowing liquid flow rates up to approximately 50 microL/min. The exit slit interface increases the transmission of ribbon-shaped ion beams output by the p-FAIMS to downstream stages such as a MS. Overall, the ion signal in ESI/FAIMS/MS analyses increases by over an order of magnitude without affecting FAIMS resolution.
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Registered trials
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