Evidence map›Paper›PMID 19616655›Full record

ReviewBiochimica et biophysica acta

Chromatin at the intersection of viral infection and DNA damage.

Caroline E Lilley, Mira S Chaurushiya, Matthew D Weitzman

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A single-cell atlas of thebioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Interplay Between KSHV and the Host DNA Damage Response.Frontiers in cellular and infection microbiology · 2020
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Cidofovir: a novel antitumor agent for glioblastoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Caroline E LilleyLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Mira S Chaurushiya
Matthew D Weitzman
Salk Institute for Biological Studies · US

Funding

Contemporary Approaches to Cancer Cell Signaling and CommunicationT32CA009523 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DONOGHUE, DANIEL J, YANG, JING · 1985 to 2025
$12.1M
Viral Modulation of Genetic StabilityR01CA097093 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI WEITZMAN, MATTHEW D. · 2003 to 2019
$5.2M
AAV and the DNA Damage MachineryR01AI067952 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI WEITZMAN, MATTHEW D. · 2006 to 2010
$2.1M
Interactions of AAV with Cellular FactorsR01AI051686 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI WEITZMAN, MATTHEW D. · 2002 to 2006
$1.9M
NCI NIH HHS CA097093NCI NIH HHS R01 CA097093NCI NIH HHS T32 CA009523NIAID NIH HHS AI051686NIAID NIH HHS AI067952NIAID NIH HHS R01 AI051686NIAID NIH HHS R01 AI067952Wellcome Trust
6 · The paper itself

Abstract

During infection, viruses cause global disruption to nuclear architecture in their attempt to take over the cell. In turn, the host responds with various defenses, which include chromatin-mediated silencing of the viral genome and activation of DNA damage signaling pathways. Dynamic exchanges at chromatin, and specific post-translational modifications on histones have recently emerged as master controllers of DNA damage signaling and repair. Studying viral control of chromatin modifications is identifying histones as important players in the battle between host and virus for control of cell cycle and gene expression. These studies are revealing new complexities of the virus-host interaction, uncovering the potential of chromatin as an anti-viral defense mechanism, and also providing unique insights into the role of chromatin in DNA repair.

Indexed as

AnimalsCell CycleChromatinDNA DamageHistonesHumansVirus DiseasesVirusesChromatinHistones

Identifiers

PMID19616655
PMCPMC2838936
OpenAlexW2030086454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.