ArticlePhysiology & behavior2009
Differential effects of estradiol on drinking by ovariectomized rats in response to hypertonic NaCl or isoproterenol: Implications for hyper- vs. hypo-osmotic stimuli for water intake.
Article in Physiology & behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Fluid transitions.Neuropharmacology · 2024Review
- The estrogenic reduction in water intake stimulated by dehydration involves estrogen receptor alpha and a potential role for GLP-1.Physiology & behavior · 2024Article
- Thirst: neuroendocrine regulation in mammals.Veterinary research communications · 2023Review
- The anti-dipsogenic and anti-natriorexigenic effects of estradiol, but not the anti-pressor effect, are lost in aged female rats.Physiological reports · 2021Article
- Bidirectional effects of estradiol on the control of water intake in female rats.Hormones and behavior · 2021Article
- Fluid intake, what's dopamine got to do with it?Physiology & behavior · 2021Article
- Aging affects isoproterenol-induced water drinking, astrocyte density, and central neuronal activation in female Brown Norway rats.Physiology & behavior · 2018Article
- Gonadal hormones, but not sex, affect the acquisition and maintenance of a Go/No-Go odor discrimination task in mice.Hormones and behavior · 2018Article
- Multiple estrogen receptor subtypes influence ingestive behavior in female rodents.Physiology & behavior · 2015Review
- Estradiol and osmolality: Behavioral responses and central pathways.Physiology & behavior · 2015Review
- Control of fluid intake by estrogens in the female rat: role of the hypothalamus.Frontiers in systems neuroscience · 2015Review
- Sex differences in the physiology of eating.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Review
- Estradiol selectively reduces central neural activation induced by hypertonic NaCl infusion in ovariectomized rats.Physiology & behavior · 2012Article
- Time course of behavioral, physiological, and morphological changes after estradiol treatment of ovariectomized rats.Physiology & behavior · 2011Article
- Regional differences in estradiol effects on numbers of HSD2-containing neurons in the nucleus of the solitary tract of rats.Brain research · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We examined the effects of estradiol on behavioral responses to osmotic challenges in ovariectomized (OVX) rats to test the hypothesis that estradiol enhances sensitivity to gradual changes in plasma osmolality (pOsm) in stimulating water intake. Despite comparably elevated pOsm after a slow infusion of 2 M NaCl, the latency to begin water intake was significantly less in estradiol-treated OVX rats compared to that in oil vehicle-treated rats. Other groups of OVX rats were injected with isoproterenol, which increases circulating angiotensin II. These rats then were given 0.15 M NaCl to drink instead of water, to prevent decreased pOsm associated with water ingestion. Isoproterenol stimulated 0.15 M NaCl intake by both groups; however, estradiol-treated rats consumed less 0.15 M NaCl than did oil-treated rats, findings that are similar to those reported when estradiol-treated rats consumed water. The estradiol enhancement of sensitivity to increased, but not to decreased, pOsm suggests that estradiol has directionally-specific effects on osmoregulatory drinking. Moreover, the estradiol attenuation of 0.15 M NaCl intake after isoproterenol suggests that estradiol effects on osmoregulatory drinking are independent of those on volume regulatory drinking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.