ArticleSchizophrenia research2009
Cognitive performance is related to cortical grey matter volumes in early stages of schizophrenia: a population-based study of first-episode psychosis.
Article in Schizophrenia research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum.Schizophrenia bulletin · 2021Pooled it
- Voxel-based morphometry for separation of schizophrenia from other types of psychosis in first episode psychosis.The Cochrane database of systematic reviews · 2015Pooled it
- From Micro Molecular to Functional Levels Through Macro Structures: Mediation of Structural Brain Changes on the Relationship Between Oxidative Stress and Cognition in Early Onset Psychosis.Schizophrenia bulletin open · 2026Article
- Article
- Cognitive subgroups of affective and non-affective psychosis show differences in medication and cortico-subcortical brain networks.Scientific reports · 2024Article
- The interaction between first-episode drug-naïve schizophrenia and age based on gray matter volume and its molecular analysis: a multimodal magnetic resonance imaging study.Psychopharmacology · 2023Article
- Facial emotion perception abilities are related to grey matter volume in the culmen of cerebellum anterior lobe in drug-naïve patients with first-episode schizophrenia.Brain imaging and behavior · 2022Article
- Schizophrenia Imaging Signatures and Their Associations With Cognition, Psychopathology, and Genetics in the General Population.The American journal of psychiatry · 2022Article
- The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia.Journal of clinical medicine · 2022Article
- Relationships between cognitive performance, clinical insight and regional brain volumes in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Sulforaphane Effects on Cognition and Symptoms in First and Early Episode Schizophrenia: A Randomized Double-Blind Trial.Schizophrenia bulletin open · 2022Article
- On the potential for mapping apparent neural soma density via a clinically viable diffusion MRI protocol.NeuroImage · 2021Article
- Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis.Journal of clinical medicine · 2021Article
- Cognitive Implications of Correlated Structural Network Changes in Schizophrenia.Frontiers in integrative neuroscience · 2021Article
- Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype.Molecular psychiatry · 2020Article
- Long-Term Grey Matter Changes in First Episode Psychosis: A Systematic Review.Psychiatry investigation · 2019Article
- Neural correlates of global and specific cognitive deficits in schizophrenia.Schizophrenia research · 2018Article
- Theoretical Modeling of Cognitive Dysfunction in Schizophrenia by Means of Errors and Corresponding Brain Networks.Frontiers in psychology · 2018Review
- Cognitive correlates of neuroimaging abnormalities in the onset of schizophrenia: A case report.World journal of psychiatry · 2017Article
- Early visual processing for low spatial frequency fearful face is correlated with cortical volume in patients with schizophrenia.Neuropsychiatric disease and treatment · 2016Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundNeuropsychological deficits have been reported in association with first-episode psychosis (FEP). Reductions in grey matter (GM) volumes have been documented in FEP subjects compared to healthy controls. However, the possible inter-relationship between the findings of those two lines of research has been scarcely investigated.
objectiveTo investigate the relationship between neuropsychological deficits and GM volume abnormalities in a population-based sample of FEP patients compared to healthy controls from the same geographical area.
methodsFEP patients (n=88) and control subjects (n=86) were evaluated by neuropsychological assessment (Controlled Oral Word Association Test, forward and backward digit span tests) and magnetic resonance imaging using voxel-based morphometry.
resultsSingle-group analyses showed that prefrontal and temporo-parietal GM volumes correlated significantly (p<0.05, corrected) with cognitive performance in FEP patients. A similar pattern of direct correlations between neocortical GM volumes and cognitive impairment was seen in the schizophrenia subgroup (n=48). In the control group, cognitive performance was directly correlated with GM volume in the right dorsal anterior cingulate cortex and inversely correlated with parahippocampal gyral volumes bilaterally. Interaction analyses with "group status" as a predictor variable showed significantly greater positive correlation within the left inferior prefrontal cortex (BA46) in the FEP group relative to controls, and significantly greater negative correlation within the left parahippocampal gyrus in the control group relative to FEP patients.
conclusionOur results indicate that cognitive deficits are directly related to brain volume abnormalities in frontal and temporo-parietal cortices in FEP subjects, most specifically in inferior portions of the dorsolateral prefrontal cortex.
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Registered trials
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