ArticleExperimental neurology2009
Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cell cultures.
Article in Experimental neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Tat-specific antibodies associated with better HIV-associated motor function.Scientific reports · 2025Article
- HIV-1 Tat amino acid residues that influence Tat-TAR binding affinity: a scoping review.BMC infectious diseases · 2023Article
- HIV and Alzheimer's disease: complex interactions of HIV-Tat with amyloid β peptide and Tau protein.Journal of neurovirology · 2019Review
- Genetic variation and function of the HIV-1 Tat protein.Medical microbiology and immunology · 2019Review
- Dose-dependent neurocognitive deficits following postnatal day 10 HIV-1 viral protein exposure: Relationship to hippocampal anatomy parameters.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2018Article
- The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders.Frontiers in microbiology · 2015Review
- Role of Oxidative Stress in HIV-1-Associated Neurocognitive Disorder and Protection by Gene Delivery of Antioxidant Enzymes.Antioxidants (Basel, Switzerland) · 2014Review
- Synaptodendritic recovery following HIV Tat exposure: neurorestoration by phytoestrogens.Journal of neurochemistry · 2014Article
- Genetic attributes of blood-derived subtype-C HIV-1 tat and env in India and neurocognitive function.Journal of medical virology · 2014Article
- HIV-1 Tat protein variants: critical role for the cysteine region in synaptodendritic injury.Experimental neurology · 2013Article
- Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production.Neurobiology of aging · 2013Article
- Mutation of tyrosine 470 of human dopamine transporter is critical for HIV-1 Tat-induced inhibition of dopamine transport and transporter conformational transitions.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Article
- D1/NMDA receptors and concurrent methamphetamine+ HIV-1 Tat neurotoxicity.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases.Neuroscience · 2012Article
- Genetic features of cerebrospinal fluid-derived subtype B HIV-1 tat.Journal of neurovirology · 2012Article
- Article
- Endogenous amyloidogenesis in long-term rat hippocampal cell cultures.BMC neuroscience · 2011Article
- Neurodegenerative effects of recombinant HIV-1 Tat(1-86) are associated with inhibition of microtubule formation and oxidative stress-related reductions in microtubule-associated protein-2(a,b).Neurochemical research · 2011Article
- HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures.Neuroscience letters · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
This study reports that the cysteine 22-->glycine 22 substitution in the HIV-1 Tat 1-86 B significantly attenuates its neurotoxicity. Consistent with previous studies, direct interactions of rat hippocampal cells with Tat 1-86 B were shown to cause dose-dependent and time-dependent neurotoxicity associated with activation of caspases from the mitochondrial apoptotic pathway. Despite the similar binding/uptake properties, Cys22 Tat 1-86 B failed to induce significant neurotoxicity and activation of caspases 9 and 3/7 in hippocampal primary cultures. Results of the study underscore the important role of cysteine-rich domain in mechanism of Tat-mediated neurotoxicity.
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