ArticleEpigenetics & chromatin2009
A role for non-coding Tsix transcription in partitioning chromatin domains within the mouse X-inactivation centre.
Article in Epigenetics & chromatin, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Orchestrating Asymmetric Expression: Mechanisms behindEpigenomes · 2024Review
- The lncRNAs at X Chromosome Inactivation Center: Not Just a Matter of Sex Dosage Compensation.International journal of molecular sciences · 2022Review
- Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression.Communications biology · 2021Article
- Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression.Molecular and cellular biology · 2015Article
- Mapping of Replication Origins in the X Inactivation Center of Vole Microtus levis Reveals Extended Replication Initiation Zone.PloS one · 2015Article
- A prominent and conserved role for YY1 in Xist transcriptional activation.Nature communications · 2014Article
- Differentiation-dependent requirement of Tsix long non-coding RNA in imprinted X-chromosome inactivation.Nature communications · 2014Article
- Article
- Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming.Molecular cell · 2013Article
- Long nonoding RNAs in the X-inactivation center.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- Non-coding RNA and antisense RNA. Nature's trash or treasure?Biochimie · 2011Review
- The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells.Human genetics · 2011Article
- The demoiselle of X-inactivation: 50 years old and as trendy and mesmerising as ever.PLoS genetics · 2011Review
- Regulation of X-chromosome inactivation by the X-inactivation centre.Nature reviews. Genetics · 2011Review
- Article
- Identification of regulatory elements flanking human XIST reveals species differences.BMC molecular biology · 2010Article
- Epigenetics & Chromatin celebrates its first anniversary.Epigenetics & chromatin · 2009Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDelimiting distinct chromatin domains is essential for temporal and spatial regulation of gene expression. Within the X-inactivation centre region (Xic), the Xist locus, which triggers X-inactivation, is juxtaposed to a large domain of H3K27 trimethylation (H3K27me3).
resultsWe describe here that developmentally regulated transcription of Tsix, a crucial non-coding antisense to Xist, is required to block the spreading of the H3K27me3 domain to the adjacent H3K4me2-rich Xist region. Analyses of a series of distinct Tsix mutations suggest that the underlying mechanism involves the RNA Polymerase II accumulating at the Tsix 3'-end. Furthermore, we report additional unexpected long-range effects of Tsix on the distal sub-region of the Xic, involved in Xic-Xic trans-interactions.
conclusionThese data point toward a role for transcription of non-coding RNAs as a developmental strategy for the establishment of functionally distinct domains within the mammalian genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.