ArticleBMC cancer2009
The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study.
Article in BMC cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 13 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 13 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- An updated association between TNF-α -238G/A polymorphism and gastric cancer susceptibility in East Asians.Bioscience reports · 2018Pooled it
- Helicobacter pylori Infection and Risk of Gastric Cancer in Korea: A Quantitative Systematic Review.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2016Pooled it
- Tumor Necrosis Factor-Disease markers · 2016Pooled it
- Attributable fraction of tobacco smoking on cancer using population-based nationwide cancer incidence and mortality data in Korea.BMC cancer · 2014Pooled it
- Positive association between lymphotoxin-alpha variation rs909253 and cancer risk: a meta-analysis based on 36 case-control studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Quantitative assessment of the influence of tumor necrosis factor alpha polymorphism with gastritis and gastric cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- TNF-α-308 polymorphism and risk of digestive system cancers: a meta-analysis.World journal of gastroenterology · 2013Pooled it
- Tumor necrosis factor-α 238 G/A polymorphism and gastric cancer risk: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Association between tumor necrosis factor β 252 A/G polymorphism and risk of gastric cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Association between tumor necrosis factor-alpha 857C/T polymorphism and gastric cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- TNF-β +252 A>G polymorphism and susceptibility to cancer.Journal of cancer research and clinical oncology · 2013Pooled it
- Relationship between the polymorphism of tumor necrosis factor-α-308 G>A and susceptibility to inflammatory bowel diseases and colorectal cancer: a meta-analysis.European journal of human genetics : EJHG · 2011Pooled it
- Pooled it
- Integrating TNF-α with Established Tumor Markers to Enhance Prognostic Accuracy in Gastric Cancer: A Prospective Observational Study.Biomedicines · 2025Article
- Identification of functional tumor necrosis factor-alpha promoter variants associated withWorld journal of gastroenterology · 2022Observational
- The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development.International journal of molecular sciences · 2021Review
- XAB2 TagSNP Is Associated with the Risk of Gastric Cancer in Chinese Population: A Case-Control Study.International journal of environmental research and public health · 2021Article
- Polymorphism ofFrontiers in oncology · 2021Article
- SNP interactions of PGC with its neighbor lncRNAs enhance the susceptibility to gastric cancer/atrophic gastritis and influence the expression of involved molecules.Cancer medicine · 2018Article
- Relationship Between Tumor Necrosis Factor-α rs361525 Polymorphism and Gastric Cancer Risk: A Meta-Analysis.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate the role of TNF genetic variants and the combined effect between TNF gene and cigarette smoking in the development of gastric cancer in the Korean population.
methodsWe selected 84 incident gastric cancer cases and 336 matched controls nested within the Korean Multi-Center Cancer Cohort. Six SNPs on the TNF gene, TNF-alpha-238 G/A, -308 G/A, -857 C/T, -863 C/A, -1031 T/C, and TNF-beta 252 A/G were genotyped. The ORs (95% CIs) were calculated using unconditional logistic regression model to detect each SNP and haplotype-pair effects for gastric cancer. The combined effects between the TNF gene and smoking on gastric cancer risk were also evaluated. Multi dimensionality reduction (MDR) analyses were performed to explore the potential TNF gene-gene interactions.
resultsTNF-alpha-857 C/T containing the T allele was significantly associated with an increased risk of gastric cancer and a linear trend effect was observed in the additive model (OR = 1.6, 95% CI 1.0-2.5 for CT genotype; OR = 2.6, 95% CI 1.0-6.4 for TT genotype). All haplotype-pairs that contained TCT or CCC of TNF-alpha-1031 T/C, TNF-alpha-863 C/A, and TNF-alpha-857 C/T were associated with a significantly higher risk for gastric cancer only among smokers. In the MDR analysis, regardless of smoking status, TNF-alpha-857 C/T was included in the first list of SNPs with a significant main effect.
conclusionTNF-alpha-857 C/T polymorphism may play an independent role in gastric carcinogenesis and the risk for gastric cancer by TNF genetic effect is pronounced by cigarette smoking.
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