ArticleJournal of computational neuroscience2009
Dissecting cooperative calmodulin binding to CaM kinase II: a detailed stochastic model.
Article in Journal of computational neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Fitting and comparison of calcium-calmodulin kinetic schemes to a common data set using non-linear mixed effects modelling.PloS one · 2025Article
- Data Hazards as An Ethical Toolkit for Neuroscience.Neuroethics · 2025Article
- Astrocyte Intracellular CaNeurotoxicity research · 2021Article
- Electroacupuncture Reverses CUMS-Induced Depression-Like Behaviors and LTP Impairment in Hippocampus by Downregulating NR2B and CaMK II Expression.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Bilobal architecture is a requirement for calmodulin signaling to CaProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Biophysical attributes that affect CaMKII activation deduced with a novel spatial stochastic simulation approach.PLoS computational biology · 2018Article
- Conformational frustration in calmodulin-target recognition.Journal of molecular recognition : JMR · 2015Article
- Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin.The Journal of general physiology · 2014Article
- The delicate bistability of CaMKII.Biophysical journal · 2013Article
- Phosphorylation at Ser²⁶ in the ATP-binding site of Ca²⁺/calmodulin-dependent kinase II as a mechanism for switching off the kinase activity.Bioscience reports · 2013Article
- Distinct mechanisms of calmodulin binding and regulation of adenylyl cyclases 1 and 8.Biochemistry · 2012Article
- Mechanisms of CaMKII action in long-term potentiation.Nature reviews. Neuroscience · 2012Review
- Ca(2+) sensor proteins in dendritic spines: a race for Ca(2+).Frontiers in molecular neuroscience · 2012Article
- Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII.PloS one · 2012Article
- Structural analysis and stochastic modelling suggest a mechanism for calmodulin trapping by CaMKII.PloS one · 2012Article
- Sequestration of CaMKII in dendritic spines in silico.Journal of computational neuroscience · 2011Article
- The impacts of geometry and binding on CaMKII diffusion and retention in dendritic spines.Journal of computational neuroscience · 2011Article
- Lobe specific Ca2+-calmodulin nano-domain in neuronal spines: a single molecule level analysis.PLoS computational biology · 2010Article
- The effect of noise on CaMKII activation in a dendritic spine during LTP induction.Journal of neurophysiology · 2010Article
- Postsynaptic signal transduction models for long-term potentiation and depression.Frontiers in computational neuroscience · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Calmodulin (CaM) is a major Ca(2+) binding protein involved in two opposing processes of synaptic plasticity of CA1 pyramidal neurons: long-term potentiation (LTP) and depression (LTD). The N- and C-terminal lobes of CaM bind to its target separately but cooperatively and introduce complex dynamics that cannot be well understood by experimental measurement. Using a detailed stochastic model constructed upon experimental data, we have studied the interaction between CaM and Ca(2+)-CaM-dependent protein kinase II (CaMKII), a key enzyme underlying LTP. The model suggests that the accelerated binding of one lobe of CaM to CaMKII, when the opposing lobe is already bound to CaMKII, is a critical determinant of the cooperative interaction between Ca(2+), CaM, and CaMKII. The model indicates that the target-bound Ca(2+) free N-lobe has an extended lifetime and may regulate the Ca(2+) response of CaMKII during LTP induction. The model also reveals multiple kinetic pathways which have not been previously predicted for CaM-dissociation from CaMKII.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.