ArticleIn vitro cellular & developmental biology. Animal2009
Immune suppression of human lymphoid tissues and cells in rotating suspension culture and onboard the International Space Station.
Article in In vitro cellular & developmental biology. Animal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Omics Studies of Specialized Cells and Stem Cells under Microgravity Conditions.International journal of molecular sciences · 2024Review
- Behavior of glioblastoma brain tumor stem cells following a suborbital rocket flight: reaching the "edge" of outer space.NPJ microgravity · 2023Article
- Lab-on-chip technologies for space research - current trends and prospects.Mikrochimica acta · 2023Review
- The Impact of Microgravity on Immunological States.ImmunoHorizons · 2023Review
- Mechano-Immunomodulation in Space: Mechanisms Involving Microgravity-Induced Changes in T Cells.Life (Basel, Switzerland) · 2021Review
- B cell homeostasis is maintained during long-duration spaceflight.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Effects of skeletal unloading on the antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice.PloS one · 2019Article
- Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice.Life sciences in space research · 2018Article
- Validation of Methods to Assess the Immunoglobulin Gene Repertoire in Tissues Obtained from Mice on the International Space Station.Gravitational and space research : publication of the American Society for Gravitational and Space Research · 2017Article
- From the bench to exploration medicine: NASA life sciences translational research for human exploration and habitation missions.NPJ microgravity · 2017Article
- Signal transduction in primary human T lymphocytes in altered gravity - results of the MASER-12 suborbital space flight mission.Cell communication and signaling : CCS · 2013Article
- Three-dimensional normal human neural progenitor tissue-like assemblies: a model of persistent varicella-zoster virus infection.PLoS pathogens · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The immune responses of human lymphoid tissue explants or cells isolated from this tissue were studied quantitatively under normal gravity and microgravity. Microgravity was either modeled by solid body suspension in a rotating, oxygenated culture vessel or was actually achieved on the International Space Station (ISS). Our experiments demonstrate that tissues or cells challenged by recall antigen or by polyclonal activator in modeled microgravity lose all their ability to produce antibodies and cytokines and to increase their metabolic activity. In contrast, if the cells were challenged before being exposed to modeled microgravity suspension culture, they maintained their responses. Similarly, in microgravity in the ISS, lymphoid cells did not respond to antigenic or polyclonal challenge, whereas cells challenged prior to the space flight maintained their antibody and cytokine responses in space. Thus, immune activation of cells of lymphoid tissue is severely blunted both in modeled and true microgravity. This suggests that suspension culture via solid body rotation is sufficient to induce the changes in cellular physiology seen in true microgravity. This phenomenon may reflect immune dysfunction observed in astronauts during space flights. If so, the ex vivo system described above can be used to understand cellular and molecular mechanisms of this dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.