Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2010
Osteotomy and primary wound closure in bisphosphonate-associated osteonecrosis of the jaw: a prospective clinical study with 12 months follow-up.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 153 citations in OpenAlex.
- Microsurgical Reconstruction of the Jaws Using Vascularised Free Flap Technique in Patients with Medication-Related Osteonecrosis: A Systematic Review.BioMed research international · 2018Pooled it
- Medication-related osteonecrosis of the jaw in cancer and osteoporosis patients: a retrospective seven-year single-center Norwegian cohort study of clinical profiles and documented soft tissue healing.Acta odontologica Scandinavica · 2026Article
- Effect of nasogastric tube feeding on oral wound healing and oral health-related quality of life (OHRQoL) after surgery for medication-related osteonecrosis of the jaw (MRONJ).Head & face medicine · 2025Article
- Advancing oral immunology for improving oral health.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025Review
- Medication-related osteonecrosis of the jaw: a retrospective single center study of recurrence-related factors after surgical treatment.Clinical oral investigations · 2024Article
- Free buccal fat pad graft for the bone defect filling of medication-related osteonecrosis of the jaws: A novel surgical approach.Journal of dental sciences · 2024Article
- Improvement of Quality of Life after Surgical Treatment of Patients with MRONJ: A Prospective Analysis Using the SF-12 and OHIP-14 Questionnaires.International journal of dentistry · 2024Article
- MRONJ of the Mandible-From Decortication to a Complex Jaw Reconstruction Using a CAD/CAM-Guided Bilateral Scapula Flap.Medicina (Kaunas, Lithuania) · 2023Article
- Review
- Revisiting Standard and Novel Therapeutic Approaches in Halitosis: A Review.International journal of environmental research and public health · 2022Review
- Osteonecrosis of the Jaw and Antiresorptive Agents in Benign and Malignant Diseases: A Critical Review Organized by the ECTS.The Journal of clinical endocrinology and metabolism · 2022Review
- Multiple myeloma masquerading as mandibular medication-related osteonecrosis of the jaw: a case report.Australian dental journal · 2022Article
- CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ.International journal of environmental research and public health · 2021Article
- Surgical strategy for medication-related osteonecrosis of the jaw (MRONJ) on maxilla: A multicenter retrospective study.Journal of dental sciences · 2021Article
- Zoledronate Causes a Systemic Shift of Macrophage Polarization towards M1 In Vivo.International journal of molecular sciences · 2021Article
- Surgical Treatment of Medication-Related Osteonecrosis of the Jaw: A Retrospective Study.International journal of environmental research and public health · 2020Article
- Oral Surgical Management of Bone and Soft Tissues in MRONJ Treatment: A Decisional Tree.Life (Basel, Switzerland) · 2020Article
- Enhancement of peri-implant bone formation via parathyroid hormone administration in a rat model at risk for medication-related osteonecrosis of the jaw.Journal of periodontal & implant science · 2020Article
- Treatment outcomes and prognostic factors of medication-related osteonecrosis of the jaw: a case- and literature-based review.Clinical oral investigations · 2019Review
- Positive impact of Platelet-rich plasma and Platelet-rich fibrin on viability, migration and proliferation of osteoblasts and fibroblasts treated with zoledronic acid.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
goals of workThis is a prospective clinical study aimed at assessing the success rate of osteotomy and primary wound closure in patients with bisphosphonate-associated osteonecrosis of the jaw (BONJ). MATERIALS AND
methodsFifty patients who had received bisphosphonates intravenously and subsequently suffered from BONJ were included in the study. All patients underwent osteotomy of the affected jaw bone region and primary wound closure under general anaesthesia. They were followed up bimonthly for a period of 12 months.
resultsMacroscopically altered bone could be completely removed in all cases. In two patients with plasmocytoma, major bleeding occurred postoperatively that required monitoring in an intensive care unit. In two cases, recurrence of BONJ was diagnosed during the first 2 months. In three patients, recurrence appeared between the fourth and the sixth month. In these cases, an additional osteotomy had to be performed. Six patients died during the follow-up period. In the remaining 39 patients, no signs of recurrence could be detected during the follow-up of 12 months. The success rate of the surviving patients was 89% after 1 year.
conclusionDue to the high success rate of osteotomy and primary wound closure, it should be checked for every patient suffering from BONJ if osteotomy is a viable treatment option.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.