ArticleDevelopment genes and evolution2009
Genomic organization of zebra finch alpha and beta globin genes and their expression in primitive and definitive blood in comparison with globins in chicken.
Article in Development genes and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Comprehensive Analyses of Bone and Cartilage Transcriptomes Evince Ion Transport, Inflammation and Cartilage Development-Related Genes Involved in Chickens' Femoral Head Separation.Animals : an open access journal from MDPI · 2022Article
- Proteomic Analysis of Chicken Chorioallantoic Membrane (CAM) during Embryonic Development Provides Functional Insight.BioMed research international · 2022Article
- Gene Turnover and Diversification of the α- and β-Globin Gene Families in Sauropsid Vertebrates.Genome biology and evolution · 2018Article
- Gene Duplication and Evolutionary Innovations in Hemoglobin-Oxygen Transport.Physiology (Bethesda, Md.) · 2016Review
- Gene turnover in the avian globin gene families and evolutionary changes in hemoglobin isoform expression.Molecular biology and evolution · 2015Article
- More than hemoglobin - the unexpected diversity of globins in vertebrate red blood cells.Physiological reports · 2015Article
- Gene duplication, genome duplication, and the functional diversification of vertebrate globins.Molecular phylogenetics and evolution · 2013Review
- Gene duplication and the evolution of hemoglobin isoform differentiation in birds.The Journal of biological chemistry · 2012Article
- Review
- Developmental regulation of hemoglobin synthesis in the green anole lizard Anolis carolinensis.The Journal of experimental biology · 2011Article
- Lineage-specific patterns of functional diversification in the alpha- and beta-globin gene families of tetrapod vertebrates.Molecular biology and evolution · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How alpha and beta globin genes are organized and expressed in amniotes is of interest to researchers in a wide variety of fields. Data regarding this from avian species have been scarce. Using genomic and proteomic approaches, we present here our analysis of alpha and beta globins of zebra finch, a passerine bird. We show that finch alpha globin gene cluster has three genes (alphas 1-3), each orthologous to its chicken counterpart. Finch beta globin gene cluster has three genes (betas 1-3), with an additional pseudogene at the 3' end. Finch beta3 is orthologous to chicken betaA, but the orthology of beta1 and beta2 to chicken counterparts is less clear. All six finch globins are confirmed to encode functional proteins. Gene expression in both globin gene clusters is regulated developmentally. Adult finch blood has a globin profile similar to that of adult chicken, with high levels of beta3 and alpha3 and moderate levels of alpha2. Finch embryonic primitive blood exhibits a globin profile very different from that of equivalent stage chick embryos, with all six globins expressed at high levels. Overall, our data provide a valuable resource for future studies in avian globin gene evolution and globin switching during erythropoietic development.
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