ArticleImmunogenetics2009
On the genomics of immunoglobulins in the gray, short-tailed opossum Monodelphis domestica.
Article in Immunogenetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Adaptive Immunity in Marsupials.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Review
- Marsupial Ig genomics revisited and the potential role of retroelements in the limited number of heavy chain isotypes.BMC biology · 2025Article
- Annotation of immune genes in the extinct thylacine (Thylacinus cynocephalus).Immunogenetics · 2021Article
- Guardian of the Genome: An Alternative RAG/Transib Co-Evolution Hypothesis for the Origin of V(D)J Recombination.Frontiers in immunology · 2021Article
- Opossum milk IgG is from maternal circulation and timing of transfer correlates with neonatal immune development.Reproduction, fertility, and development · 2019Article
- Genomic organization and adaptive evolution of IGHC genes in marine mammals.Molecular immunology · 2018Article
- Article
- Three IgH isotypes, IgM, IgA and IgY are expressed in Gentoo penguin and zebra finch.PloS one · 2017Article
- Fish Immunoglobulins.Biology · 2016Review
- B cells and their role in the teleost gut.Developmental and comparative immunology · 2016Review
- Identification and analysis of divergent immune gene families within the Tasmanian devil genome.BMC genomics · 2015Article
- Article
- IgH loci of American alligator and saltwater crocodile shed light on IgA evolution.Immunogenetics · 2013Article
- The astonishing diversity of Ig classes and B cell repertoires in teleost fish.Frontiers in immunology · 2013Article
- Recombination, transcription, and diversity of a partially germline-joined VH in a mammal.Immunogenetics · 2012Article
- A VpreB3 homologue in a marsupial, the gray short-tailed opossum, Monodelphis domestica.Immunogenetics · 2012Article
- Analysis of immunoglobulin transcripts in the ostrich Struthio camelus, a primitive avian species.PloS one · 2012Article
- Early postnatal B cell ontogeny and antibody repertoire maturation in the opossum, Monodelphis domestica.PloS one · 2012Article
- Phylogenetic conservation of the 3' cryptic recombination signal sequence (3'cRSS) in the VH genes of jawed vertebrates.Frontiers in immunology · 2012Article
- Immunoglobulin genomics in the guinea pig (Cavia porcellus).PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Annotated maps of the IGH, IGK, and IGL loci in the gray, short-tailed opossum Monodelphis domestica were generated from analyses of the available whole genome sequence for this species. Analyses of their content and organization confirmed a number of previous conclusions based on characterization of complementary DNAs encoding opossum immunoglobulin heavy and light chains and limited genomic analysis, including (a) the predominance of a single immunoglobulin heavy chain variable region (IGHV) subgroup and clan, (b) the presence of a single immunoglobulin (Ig)G subclass, (c) the apparent absence of an IgD, and (d) the general organization and V gene complexity of the IGK and IGL light chain loci. In addition, several unexpected discoveries were made including the presence of a partial V to D, germline-joined IGHV segment, the first germline-joined Ig V gene to be found in a mammal. In addition was the presence of a larger number of IGKV subgroups than had been previously identified. With this report, annotated maps of the major histocompatibility complex, T-cell receptor, and immunoglobulin loci have been completed for M. domestica, the only non-eutherian mammalian species for which this has been accomplished, strengthening the utility of this species as a model organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.