ArticleThe EMBO journal2009
An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse.
Article in The EMBO journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
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- A nematode model to evaluate microdeletion phenotype expression.G3 (Bethesda, Md.) · 2024Article
- The diverse family of Cys-loop receptors inBiophysical reviews · 2023Review
- TGF-β pathways in aging and immunity: lessons fromFrontiers in genetics · 2023Review
- Reconstitution of an N-AChR from Brugia malayi, an evolved change in acetylcholine receptor accessory protein requirements in filarial parasites.PLoS pathogens · 2022Article
- Cholinergic signaling at the body wall neuromuscular junction distally inhibits feeding behavior in Caenorhabditis elegans.The Journal of biological chemistry · 2022Article
- An economical and highly adaptable optogenetics system for individual and population-level manipulation of Caenorhabditis elegans.BMC biology · 2021Article
- Anthelmintic resistance and homeostatic plasticity (Brugia malayi).Scientific reports · 2021Article
- Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans.PLoS genetics · 2021Article
- Article
- Diisopropylphenyl-imidazole (DII): A new compound that exerts anthelmintic activity through novel molecular mechanisms.PLoS neglected tropical diseases · 2018Article
- The Claudin-like Protein HPO-30 Is Required to Maintain LAChRs at theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- EMC3 coordinates surfactant protein and lipid homeostasis required for respiration.The Journal of clinical investigation · 2017Article
- High-throughput screens using photo-highlighting discover BMP signaling in mitochondrial lipid oxidation.Nature communications · 2017Article
- Metabolome and proteome changes with aging in Caenorhabditis elegans.Experimental gerontology · 2015Article
- Illuminating neural circuits and behaviour in Caenorhabditis elegans with optogenetics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Ganglioside regulation of AMPA receptor trafficking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic Caenorhabditis elegans DEG/ENaC channels.The Journal of biological chemistry · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nicotinic acetylcholine receptors (nAChRs) are homo- or heteropentameric ligand-gated ion channels mediating excitatory neurotransmission and muscle activation. Regulation of nAChR subunit assembly and transfer of correctly assembled pentamers to the cell surface is only partially understood. Here, we characterize an ER transmembrane (TM) protein complex that influences nAChR cell-surface expression and functional properties in Caenorhabditis elegans muscle. Loss of either type I TM protein, NRA-2 or NRA-4 (nicotinic receptor associated), affects two different types of muscle nAChRs and causes in vivo resistance to cholinergic agonists. Sensitivity to subtype-specific agonists of these nAChRs is altered differently, as demonstrated by whole-cell voltage-clamp of dissected adult muscle, when applying exogenous agonists or after photo-evoked, channelrhodopsin-2 (ChR2) mediated acetylcholine (ACh) release, as well as in single-channel recordings in cultured embryonic muscle. These data suggest that nAChRs desensitize faster in nra-2 mutants. Cell-surface expression of different subunits of the 'levamisole-sensitive' nAChR (L-AChR) is differentially affected in the absence of NRA-2 or NRA-4, suggesting that they control nAChR subunit composition or allow only certain receptor assemblies to leave the ER.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.