Evidence map›Paper›PMID 19609257›Full record

ReviewNature reviews. Microbiology2009

Staphylococcus epidermidis--the 'accidental' pathogen.

Michael Otto

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 848 papers.

0numbers the graph read from it
0cells of the map it votes in
848citing papers in PubMed
27.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

848 citing papers in PubMed, 1,757 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Case report:JSES reviews, reports, and techniques · 2026
    Article
  4. Characteristics ofInternational journal of molecular sciences · 2026
    Article
  5. Article
  6. First characterization ofMicrobiology spectrum · 2026
    Article
  7. Characteristics ofInternational journal of molecular sciences · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Vancomycin and phage COP-80B combination therapy for Staphylococcus epidermidis periprosthetic joint infections: a preclinical mouse study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  13. Article
  14. Article
  15. Comparative genomic analysis ofMicrobiology spectrum · 2026
    Article
  16. Search for Potentially VirulentInternational journal of molecular sciences · 2026
    Article
  17. Antibacterial Mechanisms and Skin-Protective Activities ofInternational journal of molecular sciences · 2026
    Article
  18. Article
  19. Article
  20. Observational

788 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Michael OttoNational Institute of Allergy and Infectious Diseases, The National Institutes of Health, 9000 Rockville Pike Building 33 1W10, Bethesda, Maryland 20892, USA. motto@niaid.nih.gov
National Institutes of Health · US

Funding

Role of the human microbiota and probioticsZIAAI001080 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI OTTO, MICHAEL · 2009 to 2025
$9.7M
Intramural NIH HHS Z99 AI999999Intramural NIH HHS ZIA AI001080
6 · The paper itself

Abstract

Although nosocomial infections by Staphylococcus epidermidis have gained much attention, this skin-colonizing bacterium has apparently evolved not to cause disease, but to maintain the commonly benign relationship with its host. Accordingly, S. epidermidis does not produce aggressive virulence determinants. Rather, factors that normally sustain the commensal lifestyle of S. epidermidis seem to give rise to additional benefits during infection. Furthermore, we are beginning to comprehend the roles of S. epidermidis in balancing the epithelial microflora and serving as a reservoir of resistance genes. In this Review, I discuss the molecular basis of the commensal and infectious lifestyles of S. epidermidis.

Indexed as

AnimalsAnti-Bacterial AgentsBiofilmsDrug ResistanceHost-Pathogen InteractionsHumansSkinStaphylococcal InfectionsStaphylococcus epidermidisVirulenceAnti-Bacterial Agents

Identifiers

PMID19609257
PMCPMC2807625
OpenAlexW2073550483

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.