ArticleJournal of applied physiology (Bethesda, Md. : 1985)2009
Stabilizing immature breathing patterns of preterm infants using stochastic mechanosensory stimulation.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03881553 (Interventions to Help Infants and Children Recover in the Hospital), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interventions to Help Infants and Children Recover in the Hospital
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Body positioning for spontaneously breathing preterm infants with apnoea.The Cochrane database of systematic reviews · 2017Pooled it
- Neuromodulation of Limb Proprioceptive Afferents Decreases Apnea of Prematurity and Accompanying Intermittent Hypoxia and Bradycardia.PloS one · 2016Trial
- Stochastic Resonance Effects on Apnea, Bradycardia, and Oxygenation: A Randomized Controlled Trial.Pediatrics · 2015Trial
- Physiologic dysregulation in newborns with prenatal opioid exposure: Cardiac, respiratory and movement activity.Neurotoxicology and teratologyTrial
- The protective effect of cutaneous vagus nerve stimulation from necrotizing enterocolitis (NEC) in neonatal rats.Pediatric research · 2026Article
- Cardiorespiratory mechanisms triggered during music perception in preterm infants and adults.iScience · 2025Article
- Caregivers' response to cardiorespiratory events in preterm infants in the NICU - A quantitative overview.Acta paediatrica (Oslo, Norway : 1992) · 2025Observational
- Neonatal apnea and hypopnea prediction in infants with Robin sequence with neural additive models for time series.PLOS digital health · 2024Article
- The effect of vibrotactile stimulation on hypoxia-induced irregular breathing and apnea in preterm rabbits.Pediatric research · 2024Article
- Stochastic electrical stimulation of the thoracic or cervical regions with surface electrodes facilitates swallow in rats.Frontiers in neurology · 2024Article
- Effectiveness and safety of subthreshold vibration over suprathreshold vibration in treatment of muscle fatigue in elderly people.World journal of clinical cases · 2023Review
- Assessment of a hearing protection device on infant sleep in the neonatal intensive care unit.Journal of sleep research · 2023Article
- Comparison of oxygen supplementation in very preterm infants: Variations of oxygen saturation features and their application to hypoxemic episode based risk stratification.Frontiers in pediatrics · 2023Article
- Sensory stimulation for apnoea mitigation in preterm infants.Pediatric research · 2022Review
- The effect of sensory stimulation on apnea of prematurity.Journal of Taibah University Medical Sciences · 2022Article
- Actigraphy: Metrics reveal it is not a valid tool for determining sleep in neonates.Journal of sleep research · 2022Article
- Apnea of prematurity and sudden infant death syndrome.Handbook of clinical neurology · 2022Review
- Treating Apnea of Prematurity.Cureus · 2022Review
- Stabilizing breathing pattern using local mechanical vibrations: comparison of deterministic and stochastic stimulations in rodent models of apnea of prematurity.Biomedical engineering letters · 2021Article
- Predicting apneic events in preterm infants using cardio-respiratory and movement features.Computer methods and programs in biomedicine · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Breathing patterns in preterm infants consist of highly variable interbreath intervals (IBIs) that might originate from nonlinear properties of the respiratory oscillator and its input-output responses to peripheral and central signals. Here, we explore a property of nonlinear control, the potential for large improvement in the stability of breathing using low-level exogenous stochastic stimulation. Stimulation was administered to 10 preterm infants (postconceptional age: mean 33.3 wk, SD 1.7) using a mattress with embedded actuators that delivered small stochastic displacements (0.021 mm root mean square, 0.090 mm maximum, 30-60 Hz); this stimulus was subthreshold for causing arousal from sleep to wakefulness or other detectable changes in the behavioral state evaluated with polysomnography. We used a test-retest protocol with multiple 10-min intervals of stimulation, each paired with 10-min intervals of no stimulation. Stimulation induced an approximately 50% reduction (P = 0.003) in the variance of IBIs and an approximately 50% reduction (P = 0.002) in the incidence of IBIs > 5 s. The improved stability of eupneic breathing was associated with an approximately 65% reduction (P = 0.04) in the duration of O(2) desaturation. Our findings suggest that nonlinear properties of the immature respiratory control system can be harnessed using afferent stimuli to stabilize eupneic breathing, thereby potentially reducing the incidence of apnea and hypoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.