Trial reportInvestigative ophthalmology & visual science2009
A double-blind placebo-controlled study to evaluate valacyclovir alone and with aspirin for asymptomatic HSV-1 DNA shedding in human tears and saliva.
Trial report in Investigative ophthalmology & visual science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Emerging drugs for the treatment of herpetic keratitis.Expert opinion on emerging drugs · 2024Review
- Bilateral meibomian gland morphological alterations in unilateral herpes simplex keratitis based on artificial intelligence analysis.International journal of ophthalmology · 2024Article
- Diagnostic performance of real-time quantitative PCR in tear samples in various subtypes of herpes simplex keratitis.Journal of clinical microbiology · 2023Article
- Absence of Herpesvirus DNA in Aqueous Humor from Asymptomatic Subjects.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Medical-Grade Honey Outperforms Conventional Treatments for Healing Cold Sores-A Clinical Study.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Article
- Interrelationship of Primary Virus Replication, Level of Latency, and Time to Reactivation in the Trigeminal Ganglia of Latently Infected Mice.Journal of virology · 2016Article
- Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis.International journal of ophthalmology · 2016Article
- Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation.Journal of neurovirology · 2015Article
- Prodrugs of herpes simplex thymidine kinase inhibitors.Antiviral chemistry & chemotherapy · 2015Article
- Diffusion tensor magnetic resonance imaging of trigeminal nerves in relapsing herpetic keratouveitis.PloS one · 2015Article
- Time profile of viral DNA in aqueous humor samples of patients treated for varicella-zoster virus acute retinal necrosis by use of quantitative real-time PCR.Journal of clinical microbiology · 2013Article
- CD4 T-cell memory responses to viral infections of humans show pronounced immunodominance independent of duration or viral persistence.Journal of virology · 2013Article
- HSV-1 latent rabbits shed viral DNA into their saliva.Virology journal · 2012Article
- Rabbit and mouse models of HSV-1 latency, reactivation, and recurrent eye diseases.Journal of biomedicine & biotechnology · 2012Review
- Ocular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated?Future microbiology · 2011Review
- Ocular herpes simplex virus type 1: is the cornea a reservoir for viral latency or a fast pit stop?Cornea · 2011Review
- Upregulation of mouse genes in HSV-1 latent TG after butyrate treatment implicates the multiple roles of the LAT-ICP0 locus.Investigative ophthalmology & visual science · 2011Article
- Effect of high versus low oral doses of valacyclovir on herpes simplex virus-1 DNA shedding into tears of latently infected rabbits.Investigative ophthalmology & visual science · 2010Article
- Mucosal treatments for herpes simplex virus: insights on targeted immunoprophylaxis and therapy.Future microbiology · 2010Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeTo test the effect of valacyclovir alone and with aspirin on the asymptomatic shedding of HSV-1 DNA in tears and saliva of healthy individuals. METHOD. The subjects (n = 45) were randomized into three groups without regard to age, sex, or race. Group 1 (n = 14) received the placebo, group 2 (n = 15) received a dose of 500 mg valacyclovir once daily, and group 3 (n = 16) received a dose of 500 mg valacyclovir once daily and 350 mg aspirin twice daily for 30 days. Ocular and oral swabs were collected twice daily for 30 days. DNA was extracted from all swabs and HSV-1 DNA copy numbers were determined. Statistical analysis was performed to compare the DNA copy numbers of the three groups.
resultsThere was no significant difference in the HSV-1 DNA copy numbers in the tears or saliva among any of the three treatment groups. The mean copy numbers +/- SE of mean (SEM) of HSV-1 DNA in tears were 340 +/- 35, 1074 +/- 320, and 630 +/- 51 for groups 1, 2, and 3, and in saliva were 238 +/- 35, 963 +/- 462, and 493 +/- 25, respectively, for groups 1, 2, and 3.
conclusionsNo correlation was found between HSV-1 shedding and valacyclovir and valacyclovir with aspirin treatment. The HSV-1 DNA copy number was not reduced by treatment with 500 mg of valacyclovir daily or with a combination of daily valacyclovir (500 mg) plus twice-daily doses of aspirin (350 mg) over 30 days.
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